Shueb, Sarah2015-03-262015-03-262014-11https://hdl.handle.net/11299/170834University of Minnesota M.S. thesis. November 2014. Major: Dentistry. Advisor: Donald R. Nixdorf. 1 computer file (PDF); vii, 37 pages.Objectives: Pain is known to reduce quality of life. Concurrently, it is believed that orofacial pain reduces the oral health-related quality of life (OHRQoL). While the impact that painful temporomandibular disorders (TMD) have on OHRQoL has been well described, little has been reported about the impact of acute dental pain (ADP). Moreover, the impact of trigeminal neuralgia (TN) and persistent dentoalveolar pain disorder (PDAP) on OHRQoL has not been reported yet. The aim of this study was, therefore, to compare the OHRQoL impairment among four orofacial pain conditions, i.e., participant with TMD, ADP, TN, and PDAP and compare the results with people without orofacial pain. Methods: OHRQoL was measured using the OHIP-49 questionnaire, using a convenience sample of four orofacial pain conditions (pain groups with TMD (n=30), ADP (n=27), TN (n=21), PDAP (n=16)). To provide a frame of reference for pain-related OHRQoL impairment, we also included a group of pain-free control participants (n=20). The mean OHIP-49 summary score, with its 95% confidence interval (95% CI), described the level of impact. The differences in mean values across the four pain conditions were analyzed using Analysis of Variance (ANOVA). The second part of the analysis was performed by comparing the OHIP-49 mean score of each condition and the OHIP mean score of the control group using Student's two sample t-test. Finally the absolute score differences between groups were judged according to: the Minimal Important Difference (MID) and the Effect sizes (ES).Results: OHRQoL was measured using OHIP-49 in a convenience sample of four conditions (patient groups with orofacial pain; TMD (n=30), acute dental pain (n=27), TN (n=21), PDAP (n=16)). Our results showed significant impairment in the OHRQoL for the four conditions compared to the control group. The mean OHIP-49 score (95% CI) was 60.8 (48-74) for TMD, 61 (48-74) for ADP, 58 (41-75) for TN, and 66 (46-86) for PDAP. For comparison purposes, the mean OHIP-49 score (95% CI) was 8 (3-13) for the pain free group. The difference was statistically significant and clinically relevant between pain groups and the control group (all comparisons: P<0.001). Each of the four orofacial pain conditions had similar levels of impact on the OHRQoL when compared to each other. Using the Minimum Important Deference (MID) there was a clinical significance between chronic conditions (TMD, TN, PDAP) and the ADP (11 (-6 to 28), 8.4 (-11 to 28), and 17(-4 to 37)) respectively, also a clinical significance between the four orofacial conditions and the control group was detected. A moderate effect size was detected between participants with PDAP and ADP (ES=0.5, 95%CI (-0.1 to 1.1)). Conclusion: Our data supported the hypothesis that orofacial pain conditions have a substantial impact and adversely affect the quality of life of participants with four orofacial pain conditions as compared to those with no pain.enOHIP-49OHRQoLOrofacial painPersistent dento-alveolar painTemporomandibular joint disordersTrigeminal neuralgiaDentistryThesis or Dissertation