Roberts, Kara S.2010-07-292010-07-292010-07-29https://hdl.handle.net/11299/92548The information provided in this handout does not necessarily reflect the views of the University of Minnesota Medical School physicians and faculty. These materials are provided for informational purposes only and are in no way intended to take the place of the advice and recommendations of your personal health care provider. You use the information provided in these handouts at your own risk.Screening for possible aneuploidies, especially trisomy 21 or Down Syndrome, is generally offered to all women early in their pregnancy. The question is when that screening should be done to provide the most reliable and useful information. This article showed that combined serum (pregnancy associated plasma protein A and free beta subunit of human chorionic gonadotropin) and ultrasound testing (looking for nuchal translucency) early in their first trimester in addition to serum testing (quad screen) in their second trimester provided the most reliable results.en-USPregnancy After Age 35screeningscreeningOther