Patel, Ajay2010-11-292010-11-292010-11-29https://hdl.handle.net/11299/97313Here, 9 lead compounds, with at least micromolar-level inhibition of LF as determined by experimental High Throughput Screening (HTS), were tested against virtual databases using programs such as Volsurf (Tripos SYBYL) and QikProp (Schrodinger Maestro) to predict various pharmacokinetic properties such as Blood Brain Barrier (BBB) permeability, percent Human Intestinal Absorption (%HIA) and HERG K+ channel blockage (HERG).en-USDepartment of Medicinal ChemistryInstitute for Therapeutics Discovery and DevelopmentCollege of PharmacyPresentation