Foltz, Mary2022-11-142022-11-142022-08https://hdl.handle.net/11299/243180University of Minnesota Ph.D. dissertation. August 2022. Major: Rehabilitation Science. Advisor: Arin Ellingson. 1 computer file (PDF); x, 146 pages.Background: The intervertebral disc is altered naturally with aging, abnormally due to deformity, and mechanically due to surgery. Specifically, the structural integrity of the disc is altered, which may relate to the position of the nucleus pulposus (NP) with respect to the annulus fibrosus (AF). A typical, healthy disc has a centralized NP with a distinct transition to the AF (surrounds the NP). However, uncovering the altered morphology is not well understood. Objectives: The aims of this dissertation are: 1) characterize changes in disc morphology associated with age and degeneration in a back healthy cohort; 2) identify altered disc morphology and health in scoliotic discs compared to healthy controls; and 3) evaluate disc health and morphological alterations following corrective spinal fusion surgery. Methods: Following IRB approval, participants were enrolled (back healthy individuals and individuals diagnosed with adolescent idiopathic scoliosis). MRI (3T, Siemens, MAGNETOM) scans were then acquired. From sagittal images, qualitative degeneration of each disc was graded (based on the Pfirrmann scale). From axial images, quantitative degeneration of each disc was assessed via the NP signal intensity and signal volume. Additionally, the transition zone slopes (quantifying the distinction between the NP and AF) as well as the NP location were extracted from axial images, referred to as the disc morphology metrics. These disc health and morphology metrics were extracted from the MRIs to determine the change due to aging, scoliosis, and surgery. Results: Across the age spectrum, decreases in the transition zone slope magnitudes and anterior shift in the NP was observed with an increase in aging and disc degeneration. There was no change in the disc health metrics (NP signal intensity and signal volume) between control and scoliotic discs. In individuals diagnosed with scoliosis, the NP was located towards the convexity of the curvature and there was an increase in the convex transition zone slope compared to controls and the concave slopes. Following corrective spinal fusion surgery, there was no significant change in disc health or morphology metrics overtime (up to 2-years following surgery). However, there were significant differences between the adjacent and sub-adjacent disc levels for the disc health and morphology metrics (NP signal intensity, signal volume, transition zone slope, and NP location). Conclusions: Based on the MRI signal patterns, a shift in NP location along with altered transition zone slope magnitudes could be identified and provide information on underlying alterations to the structural integrity of the disc. Continued evaluation of the disc morphology through noninvasive MRI techniques may assist clinicians on patient specific treatment options.endegenerationintervertebral discmorphologyMRIscoliosisspinal fusion surgeryThesis or Dissertation