Hughes, Kevin2018-08-212018-08-212015https://hdl.handle.net/11299/199781University Honors Capstone Project Paper, University of Minnesota Duluth, 2015.Triple negative breast cancers (TNBCs) account for 10-20% of breast cancers and generally affect younger patient populations (<50 years) as well as African-American/Hispanic women.1,2 Current treatment options consist of surgical resection and radiation/chemical therapy; however, many of the drugs used are not cancer cell specific and result in widespread toxicity throughout body systems. A number of novel, small organic molecules selective towards cancer cells by inhibition of monocarboxylate transporters (MCT) were developed under the direction of Dr. Venkatram Mereddy. These compounds analogous to Alpha-cyano-4-hydroxycinnamic acid (CHC, a known MCT inhibitor) were synthesized from readily-available reagents and show high potential as lead compounds based on in vitro and in vivo studies.enUniversity of Minnesota DuluthUniversity HonorsScholarly Text or Essay