An Exploration into Human Pluripotency and Its Role in the Development of Squamous Cell Carcinoma in Recessive Dystrophic Epidermolysis Bullosa Patients

Ward, Emily2017-04-112017-04-112016-01https://hdl.handle.net/11299/185572University of Minnesota M.S. thesis. January 2016. Major: Stem Cell Biology. Advisor: Jakub Tolar. 1 computer file (PDF); viii, 91 pages.This thesis discusses 2 projects: 1) generating a methodology for creating a human induced pluripotent stem cell (hiPSC) line receptive to gene editing and 2) exploring the role of Nanog and the epithelial to mesenchymal transition (EMT) proteins in the pathophysiology of squamous cell carcinoma (SCC) of patients with recessive dystrophic epidermolysis bullosa (RDEB).enCancerPluripotentRDEBAn Exploration into Human Pluripotency and Its Role in the Development of Squamous Cell Carcinoma in Recessive Dystrophic Epidermolysis Bullosa PatientsThesis or Dissertation