Hazen, KatherineEckfeldt, CraigLargaespada, David2011-12-012011-12-012011-09-16https://hdl.handle.net/11299/118420Objective and Hypothesis: Investigate the therapeutic potential of NRAS-targeted therapy in the human MLL-AF9 and NRASG12V-driven AML cell line THP-1 using shRNA and small molecule inhibitors. We hypothesize that inhibition of NRAS using shRNA and inhibition of PI3K/AKT/mTOR and RAF/MEK/ERK pathways using small molecule inhibitors will lead to leukemic cell death.en-USCollege of Biological SciencesPresentation