Tollefson, Trent2010-09-152010-09-152010-09-15https://hdl.handle.net/11299/93891The information provided in this handout does not necessarily reflect the views of the University of Minnesota Medical School physicians and faculty. These materials are provided for informational purposes only and are in no way intended to take the place of the advice and recommendations of your personal health care provider. You use the information provided in these handouts at your own risk.Proton Pump Inhibitors are a commonly used medication for treatment of frequent heartburn. These are very effective and safe medications. There are some concerns about long-term safety, however. Cancer of the stomach is one of these concerns. While there is no strong evidence that PPIs can cause stomach cancer, there hasn’t been enough research done to disprove a link between the two. The other long-term concerns coupled with high cost, make consideration of other antacid therapies more important.en-USHeartburnProton Pump InhibitorAntacidSafetyOther