Karamafrooz, Adak2020-11-172020-11-172020-03https://hdl.handle.net/11299/217138University of Minnesota Ph.D. dissertation. March 2020. Major: Biochemistry, Molecular Bio, and Biophysics. Advisors: David Thomas, Reuben Harris. 1 computer file (PDF); vi, 148 pages.The overall goal of this thesis is to gain a better understanding of the structure, dynamics and function of PKA-DNAJB1 in vitro and in vivo, using human PKA-WT as reference for the studies. I have utilized NMR for most of structural and dynamics studies, ITC for binding experiments and Phosphoproteomics for in vivo studies.encAMP signalingFibrolamellar Hepatocellular carcinomaFLHCCNMRPKAProtein Kinase AThesis or Dissertation