Model, tables, figures, and data supporting Computational model captures cardiac growth in hypertensive pregnancies and in the postpartum period

Kaissar, MollyYoshida, Kyoko2024-02-162024-02-162024-02-16https://hdl.handle.net/11299/261026Experimental data used in simulations in 'MultiscaleModel.zip' are provided in .csv form in 'LitDataPregnancy.zip', 'LitDataHTN.zip', and 'LitDataPostpartum.zip'.Heart growth in the pregnant patient helps maintain cardiovascular function while supporting the growing fetus. However, in some cases, the cardiovascular demand of pregnancy can trigger life-threatening conditions, including hypertensive disorders of pregnancy and peripartum cardiomyopathy. We previously developed a computational model that accounts for hormonal and hemodynamic interactions throughout pregnancy to uncover the mechanisms behind this heart growth. Here, we evaluated its breadth, applying it to normal and abnormal rat pregnancies and after delivery. This dataset includes supplemental data and tables that support our findings and accompany our manuscriptCC0 1.0 UniversalMultiscaleGrowth and RemodelingHypertensionLactationPregnancyModel, tables, figures, and data supporting Computational model captures cardiac growth in hypertensive pregnancies and in the postpartum periodDatasethttps://doi.org/10.13020/gqsa-tn55