Kalra, Rajat2021-04-122021-04-122020-12https://hdl.handle.net/11299/219279University of Minnesota M.S. thesis. 2020. Major: Clinical Research. Advisor: Demetris Yannopoulos. 1 computer file (PDF); 57 pages.Background: The mechanisms and degree of myocardial recovery during treatment with venoarterial extracorporeal membrane oxygenation (VA-ECMO) are unclear. We performed a descriptive study to evaluate myocardial recovery and changes in parameters of myocardial loading using echocardiography. Methods: We used a retrospective cohort design to evaluate patients with refractory ventricular tachycardia/ventricular fibrillation out-of-hospital cardiac arrest who were treated with the Minnesota Resuscitation Consortium protocol. Left ventricular ejection fraction (LVEF), end-diastolic diameter (LVEDD), end-systolic diameter (LVESD), and fractional shortening were assessed using serial echocardiography. One-way analysis of variance (ANOVA) was used to compare parameters over six hospitalization stages. Two-way ANOVA was used to compare these parameters between patients that died during the index hospitalization and patients that survived. Results: 77 patients had >1 echocardiographic turndown evaluations. Thirty-eight patients survived to discharge and 39 patients died. Of 39 in-hospital deaths, 17 patients died before VA-ECMO decannulation and 22 patients died after VA-ECMO decannulation. Among all patients, LVEF improved from 9.7±10.1% from the first echocardiogram after rewarming to 43.1±13.1% after decannulation (p<0.001) and fractional shortening ratio improved from 0.14±0.12 to 0.31±0.14 (p<0.001). The LVEDD and LVESD remained stable (p=0.36 and p=0.12, respectively). Patients that died had a lower LVEF by an average of 6.93% (95% confidence interval: -10.0 to -3.83, p<0.001), but other parameters were similar. Conclusion: Refractory cardiac arrest patients treated with VA-ECMO experience significant recovery of ventricular function during treatment. We postulate that this primarily occurs via reduction of LV preload.enCardiac arrestEchocardiographyHeart failureThesis or Dissertation