This readme.txt file was generated on 20241118 by Jesse D. Hoffmeister, PhD ------------------- GENERAL INFORMATION ------------------- 1. Title: Supplemental Material in Support of the Manuscript: “Characterization of Upper Esophageal Sphincter Pressures Relative to Vocal Acoustics.” 2. Author Information Principal Investigator Contact Information Name: Jesse D. Hoffmeister, PhD Institution: University of Minnesota Address: 420 Delaware Street SE, MMC 396, Minneapolis, MN, 55455 Email: hoff0692@umn.edu ORCID: 0000-0001-8891-5907 Associate or Co-investigator Contact Information Name: Jürgen Konczak, PhD Institution: University of Minnesota Address: 400 Cooke Hall, 1900 University Ave SE, Minneapolis, MN 55455-0376 Email: jkonczak@umn.edu ORCID: 0000-0002-4422-5610 Associate or Co-investigator Contact Information Name: Stephanie Misono Institution: University of Minnesota Address: 420 Delaware Street SE, MMC 396, Minneapolis, MN, 55455 Email: smisono@umn.edu ORCID: 0000-0001-9000-6323 3. Date published or finalized for release: November 18 , 2024 4. Date of data collection (approximate date): August 2022 - April 2024 5. Geographic location of data collection (where was data collected?): Minneapolis, Minnesota, USA 6. Information about funding sources that supported the collection of the data: Support for this work was funded in part by the Dystonia Coalition through the National Institutes of Health (NIH) office of Rare Diseases Research in the National Center for Advancing Translational Sciences, the National Institute of Neurological Disorders and Stroke (NS065701, TR001456, and NS116025), from the NIH National Institute on Deafness and other Communication Disorders grant K23DC016335. 7. Overview of the data (abstract): The supplementary material is a report of results in prose describing the results of statistical sensitivity analyses comparing upper esophageal sphincter across 4 different phonatory conditions, and assessing relationships between upper esophageal sphincter pressure and two acoustic measures (Cepstral Peak Prominence and Low-to-High Spectral Energy Ratio) excluding statistical outliers. No individual or identifying data from participants are included. -------------------------- SHARING/ACCESS INFORMATION -------------------------- 1. Licenses/restrictions placed on the data: None 2. Links to publications that cite or use the data: Hoffmeister, JD, Konczak, J, Misono, SN. “Characterization of Upper Esophageal Sphincter Pressures Relative to Vocal Acoustics.” Journal of Applied Physiology (In Press November 2024) 3. Was data derived from another source? No 4. Terms of Use: https://conservancy.umn.edu/pages/policies/#:~:text=Works%20should%20be%20free%20from,retains%20copyright%20on%20all%20works. --------------------- DATA & FILE OVERVIEW --------------------- 1. File List A. Filename: “Supplemental Data_Characterization Paper” Short description: Word document of supplemental material in support of “Characterization of Upper Esophageal Sphincter Pressures Relative to Vocal Acoustics.” This file contains the results for sensitivity analyses performed with outliers omitted from analysis. 2. Relationship between files: N/A -------------------------- METHODOLOGICAL INFORMATION -------------------------- 1. Description of methods used for collection/generation of data: 32 vocally healthy adults underwent simultaneous high-resolution manometry and audio recording. Upper esophageal sphincter pressures were compared across different types of phonation (whisper, sustained vowel, periodic connected speech, vocal creak in connected speech). In addition, relationships between upper esophageal sphincter pressure and cepstral peak prominence (CPPs), and between upper esophageal sphincter pressure and low-to-high spectral energy ratio (LHR) were assessed. The data contained in this supplementary material document are sensitivity analyses that omitted a single statistical outlier. 2. Methods for processing the data: Manometric Data: UES pressure was identified as the high pressure zone between quiescent zones of the pharynx and esophagus. The highest pressure in the high pressure zone was used for analysis. Pressure data were averaged across each phonation type of interest (sustained /a/, whispered speech, out loud periodic speech, out loud speech with spontaneously-produced vocal creak). 3. Instrument- or software-specific information needed to interpret the data: Manometric data were analyzed using R statistical software, version 2023.03.0+386. CPPs was obtained using Praat software with the CPP Voice Detection Plugin, and LHR was obtained using the Analysis of Dysphonia in Speech and Voice software from Pentax Medical. Vocal creak was identified using an open-source neural network in MATLAB. 4. Standards and calibration information, if appropriate: Manometric catheters were underwent in-vivo calibration and air pressure calibration per manufacturer standards. 5. Environmental/experimental conditions: Sound-treated clinical space. 6. Describe any quality-assurance procedures performed on the data: Waveforms and spectrograms were manually inspected for each to verify each algorithm-identified instance of creak. 7. People involved with sample collection, processing, analysis and/or submission: Ali Stockness, M.S., Ashley Ramacker, M.S., Maisie Simpson, B.S., and August Richter, B.S. ----------------------------------------- DATA-SPECIFIC INFORMATION FOR: SUPPLEMENTAL MATERIAL FOR “Characterization of Upper Esophageal Sphincter Pressures Relative to Vocal Acoustics.” ----------------------------------------- 1. Description: The supplementary material is a report of results in prose describing the results of statistical sensitivity analyses comparing upper esophageal sphincter across 4 different phonatory conditions, and assessing relationships between upper esophageal sphincter pressure and two acoustic measures (CPPs and LHR) while excluding statistical outliers.