Worsened Punch Sticking by External Lubrication with Magnesium Stearate
Authors
Published Date
Publisher
Abstract
External lubrication of tooling with magnesium stearate (MgSt) is a common strategy to eliminate punch sticking when compressing powders with a high sticking propensity, such as many pure active pharmaceutical ingredients (APIs). However, we found that coating tooling with MgSt surprisingly led to aggravated punch sticking at low compaction pressures. We developed a model to explain this counterintuitive phenomenon based on the consideration of interplay of forces among the punch tip, MgSt, and API. The model is supported by the observed effects of pressure and mechanical properties of APIs on this phenomenon using 4 APIs.
Keywords
Description
University of Minnesota M.S. thesis. November 2023. Major: Pharmaceutics. Advisor: Calvin Sun. 1 computer file (PDF); vii, 25 pages.
Related to
item.page.replaces
License
Series/Report Number
Funding Information
item.page.isbn
DOI identifier
Previously Published Citation
Other identifiers
Suggested Citation
Xiang, Tianyi. (2023). Worsened Punch Sticking by External Lubrication with Magnesium Stearate. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/260616.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.