Effect of HDAC9 and HDAC11 on Osteoclast Differentiation and Activity
2017-05
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
Effect of HDAC9 and HDAC11 on Osteoclast Differentiation and Activity
Authors
Published Date
2017-05
Publisher
Type
Thesis or Dissertation
Abstract
DNA is packaged tightly creating an environment unconducive to transcriptional activation. Chromatin modifications must be made in order to facilitate transcription in eukaryotes. Histone deacetylases (HDACs) have become an important focus in research due to their role in many fundamental processes including differentiation, growth arrest and apoptosis. Previous research has shown that HDACs can influence transcription factors and play a crucial role in bone homeostasis. This study aims to understand the role of HDAC9 and HDAC11 on osteoclast differentiation and activity. While few studies have been able to identify HDAC11’s role in osteoclastogenesis, it has been shown in previous studies that overexpression of HDAC9 inhibits osteoclast differentiation while conversely loss of HDAC9 expression leads to enhanced osteoclastogenesis. To investigate the effects of HDACs 9 and 11, I conducted a series of experiments and found loss of HDAC9 or HDAC11 expression leads to enhanced osteoclast differentiation and elevated bone resorption.
Keywords
Description
University of Minnesota M.S. thesis. May 2017. Major: Dentistry. Advisor: Kim Mansky. 1 computer file (PDF); iv, 25 pages.
Related to
Replaces
License
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Other identifiers
Suggested citation
Schering, Jacob. (2017). Effect of HDAC9 and HDAC11 on Osteoclast Differentiation and Activity. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/188762.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.