Drugs acting on TRPM4 modulate NMDA receptors in hippocampal neurons
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Excitotoxic signaling mediated by N-methyl-D-aspartate receptors (NMDARs) is inhibited by NMDAR/TRPM4 complex inhibitors such as brophenexin (BPN). We used rat hippocampal neurons grown in culture to determine the effects of BPN on NMDAR and TRPM4 function. Our research found BPN is a non-competitive, fully reversible inhibitor of NMDAR-mediated Ca2+ influx and produces a modest inhibition of TRPM4 function. Functional inhibition of these ion channels likely contributes to the neuroprotective properties of NMDAR/TRPM4 interface inhibitors.
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University of Minnesota Ph.D. dissertation. June 2025. Major: Pharmacology. Advisor: Stanley Thayer. 1 computer file (PDF); iii, 127 pages.
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Casby, Jordan. (2025). Drugs acting on TRPM4 modulate NMDA receptors in hippocampal neurons. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/277343.
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