Tissue Biocompatibility and Antimicrobial Properties of Sympathomimetic Nasal Solutions for Potential Use in Dental Pulpal Management

Jones, Robert S
Garcia, Roman
Mutreja, Isha
Kumar, Dhiraj
2025-10-24
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https://hdl.handle.net/11299/276835
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2023-11-03
2024-12-20

Date completed

2024-12-20

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Title

Tissue Biocompatibility and Antimicrobial Properties of Sympathomimetic Nasal Solutions for Potential Use in Dental Pulpal Management

Published Date

2025-10-24

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B-A-M (Biofilm-Apatite-Microbiome) Lab
School of Dentistry

Author Contact

Jones, Robert S
rsjones@umn.edu

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Experimental Data

Abstract

The aim of this study was to assess these sympathomimetic nasal solution’s biocompatibility with human dental pulp stem cells (hDPSCs) and ability to kill a deep caries-associated pathogen, Rothia dentocariosa. NS-PHE and NS-OXY (both original and kids) had antimicrobial activity toward R. dentocariosa and comparable biocompatibility with hDPSCs. The data has been published in an article titled "Tissue Biocompatibility and Antimicrobial Properties of Sympathomimetic Nasal Solutions for Potential Use in Dental Pulpal Management." The data in this record supports the figures in the published manuscript.

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Jones RS, Garcia R, Mutreja I, Kumar D, Tissue Biocompatibility and Antimicrobial Properties of Sympathomimetic Nasal Solutions for Potential Use in Dental Pulpal Management, submission

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CC0 1.0 Universal
 http://creativecommons.org/publicdomain/zero/1.0/

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Data Repository for U of M (DRUM)

Funding information

This study was funded by NIH grant R01 DE027669.

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Jones, Robert S; Garcia, Roman; Mutreja, Isha; Kumar, Dhiraj. (2025). Tissue Biocompatibility and Antimicrobial Properties of Sympathomimetic Nasal Solutions for Potential Use in Dental Pulpal Management. Retrieved from the Data Repository for the University of Minnesota (DRUM), https://hdl.handle.net/11299/276835.

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Jones_RS_SNS_2025_readme.txt
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Figure 1B-Disc inhibition.xlsx
(9.21 KB)

Figure 2A-NS-Oxy BKC n OXY.xlsx
(9.76 KB)

Figure 2B-NS-PHE n PHE.xlsx
(9.46 KB)

Figure 2C-OD at 8h.xlsx
(9.47 KB)

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