NeuroD1-based therapeutic strategies for Acquired Brain Injuries and novel neuroimaging techniques.

Abstract

Acquired Brain Injuries (ABI) affect millions of people each year and often lead to long term neurological deficits with little to no treatment options. NeuroD1 is a transcription factor that has potential treatment applications for ABI’s. We sought to explore its effectiveness in traumatic brain injury (TBI) and stroke models and found enhanced neurological recoveries. The routes used to study these injuries however, can often be inefficient and inaccessible to many labs. As such, we developed pipelines to improve efficiency of TBI lesion quantification and improve accessibility of whole brain connectome analysis.