Immunomodulatory Impact Of Memory T Lymphocytes In Periodontitis

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Immunomodulatory Impact Of Memory T Lymphocytes In Periodontitis

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Periodontitis is a chronic inflammatory condition that affects dental- supporting structures. Progressive forms of periodontitis are often refractory to conventional therapy and can result in irreversible alveolar bone loss and tooth loss. Importantly, research shows that a dysregulated adaptive immune response drives periodontitis progression. Here we investigate and discuss distinct immunomodulatory aspects of periodontitis pathophysiology. Chapter I introduces Periodontitis and some of its immunological, microbiological, and clinical factors associated with this condition. In Chapter II, we report the regulatory impact of CD69 receptors in Porphyromonas gingivalis-induced mCD4+ T cells and the modulatory effects of CD69 receptors in an in vivo ligature-induced periodontitis model (LIP), LIP-induced alveolar bone loss and in LIP-associated gingival inflammatory infiltrate. In chapter III of this thesis, we report that local reactivation of oral CD8+ T cells (CD8+ TRM) exacerbates LIP progression and severity. We also characterize mechanisms of CD8+ TRM-modulated LIP progression. Finally, chapter IV of this thesis discusses the findings reported here and provides insights into the strengths and weaknesses of our experimental approaches.



University of Minnesota Ph.D. dissertation.--- 2023. Major: Oral Biology. Advisor: Mark Herzberg. 1 computer file (PDF); vi, 97 pages.

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Saavedra, Flávia. (2023). Immunomodulatory Impact Of Memory T Lymphocytes In Periodontitis. Retrieved from the University Digital Conservancy,

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