A solution to the problem of estimating fitness landscapes was proposed by Lande
and Arnold (1983). Another solution, which avoids problematic aspects of the
Lande-Arnold methodology, was proposed by Shaw, Geyer, Wagenius, Hangelbroek, and Etterson (2008). This technical report goes through Lande-Arnold theory in detail paying
careful attention to problematic aspects. The only completely new material is a theoretical analysis of when the best quadratic approximation to a fitness landscape, which is what the Lande-Arnold method estimates, is a good approximation to the actual fitness landscape.
Geyer, Charles J.; Shaw, Ruth G..
Commentary on Lande-Arnold Analysis.
School of Statistics, University of Minnesota.
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