Cell migration is an essential process for the proper development of multicellular organisms. Most migrating cells need to travel through a dense extracellular matrix (ECM), a complex mixture of proteins and macromolecules that surround all cells and tissues. The extracellular protease AdamTS-B is expressed in both the embryonic trachea and wing imaginal disc. Loss of AdamTS-B in the trachea displays misshapen and shorter tracheal branches, whereas over-expression shows luminal cysts and extra long branches. We hypothesize that AdamTS-B is functioning in the tracheal lumen to allow proper cell elongation. Surprisingly, in the wing, gain and loss of AdamTS-B resulted in cell fate changes, functioning either through the EGFR or BMP pathways. We also examined more closely the role of slit in peripheral nervous system (PNS) neuronal migration. Through these studies we are starting to understand the complexities of cell-cell and cell-environment interactions.
Department of Biology Seminar by Afshan Ismat, Associate Professor at University of St. Thomas-St. Paul, Friday, November 6 [the Friday, November 2 date is a typo], 2020, at 3:00 pm on Zoom, hosted by: Dr. Huai Deng
Department of Biology
Ismat, Afshan; University of Minnesota Duluth. Department of Biology.
Understanding cell-cell and cell-environment interactions (2020-11-06).
Retrieved from the University of Minnesota Digital Conservancy,
Content distributed via the University of Minnesota's Digital Conservancy may be subject to additional license and use restrictions applied by the depositor.