The majority of the next generation of pharmaceutical actives that have been discovered to treat diseases, infections, and illnesses are poorly soluble in water, making their inherent bioavailability low and their effective delivery challenging. Poor solubility of a drug can be overcome by formulating the pharmaceutical active into solid dispersions with a polymeric excipient, improving the overall bioavailability of the drug. Excipient choice is paramount to the ultimate behavior of the polymer-drug solid dispersion, and the relationship between excipient properties and solid dispersion behavior is poorly understood. This dissertation describes a systematic evaluation of polymeric materials for the solubility enhancement of phenytoin, a poorly soluble antiepileptic. Through the synthesis and/or modification of polymers for use as excipients, several fundamental relationships between excipient structure and dispersion performance relationships were explored.
University of Minnesota Ph.D. dissertation. 2019. Major: Chemistry. Advisor: Marc Hillmyer. 1 computer file (PDF); 207 pages.
Polymeric Excipients for the Enhanced Oral Delivery of Poorly Soluble Pharmaceutical Compounds.
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