This Thesis describes the development of transition-metal-catalyzed alkene additions reactions through the activation of C–C and C–heteroatom σ-bonds. In these transformations, a C–C or C–heteroatom σ-bond is activated, cleaved, and added across an alkene double bond without inducing fragmentation, allowing addition of an alkene with vicinal functional groups and rapid construction of carbo- and heterocycles in an atom-economical manner. Chapter 1 provides an overview of catalytic alkene addition reactions and C–C σ-bond activation reactions. Chapters 2, 3, and 5 describe alkene addition reactions by catalytic activation of C–CN, C–O, and N–CN σ-bonds, respectively. An unprecedented metal-free N–CN bond cleavage process is discussed in Chapter 4.
University of Minnesota Ph.D. dissertation. November 2016. Major: Chemistry. Advisor: Christopher Douglas. 1 computer file (PDF); xiii, 284 pages.
Development of Catalytic C–CN, C–O, and N–CN Sigma-Bonds Activation and Alkene Addition Reactions.
Retrieved from the University of Minnesota Digital Conservancy,
Content distributed via the University of Minnesota's Digital Conservancy may be subject to additional license and use restrictions applied by the depositor.