The proposed research will investigate the role of two key proteins, sarcolipin (SLN) and phospholamban
(PLB), in muscle contractility. Both SLN and PLB monomers have a primary regulatory function of inhibiting
calcium (Ca) transport of the sarcoplasmic reticulum Ca-ATPase (SERCA). SLN inhibits SERCA in skeletal
muscle, while PLB inhibits SERCA in cardiac muscle. Adrenaline phosphorylates SLN and PLB, reversing SERCA
inhibition and stimulating muscle contraction. This research project will examine a potential second function of
SLN and PLB: the formation of ion transport channels.
This research was supported by the Undergraduate Research Opportunities Program (UROP).
Ion Channel Activity of Muscle Regulatory Proteins Sarcolipin and Phospholamban.
Retrieved from the University of Minnesota Digital Conservancy,
Content distributed via the University of Minnesota's Digital Conservancy may be subject to additional license and use restrictions applied by the depositor.