Nerve injury can trigger chronic neuropathic pain (Devor, 2006). Previous studies have reported neuronal apoptosis in the spinal cord and cerebral cortex following nerve injury (Sugimoto et al., 1990; Whiteside and Munglani, 2001; Scholz et al., 2005; Fuccio et al., 2009). Because the rostral ventromedial medulla (RVM) is a crucial site for both descending inhibition and facilitation of nociceptive transmission, we examined whether spinal nerve ligation (SNL) induced cell loss in this region.
University of Minnesota Ph.D. dissertation. Major: Neuroscience. Advisor: Martin Wessendorf, PhD. 1 computer file (PDF); vii, 131 pages.
Leong, Heather Lenore.
A study of neuronal and glial changes in the rostral ventromedial medulla in an animal model of neuropathic pain..
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