The Osterholm Update: COVID-19 Podcast

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A weekly report on the COVID-19 pandemic from infectious disease expert Michael Osterholm, PhD, MPH. Dr. Osterholm is the director of the Center for Infectious Disease Research and Policy (CIDRAP) at the University of Minnesota and has spent a career investigating outbreaks. Since 2005, he has emphasized supply chain and other vulnerabilities and a critical need for pandemic preparedness. In this podcast, Dr. Osterholm dissects the latest COVID-19 news, data, and guidance.

This podcast is available at https://www.cidrap.umn.edu/covid-19/podcasts-webinars.

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    Episode 157: Lungs & Udders
    (2024-05-16) Dall, Chris; Osterholm, Michael
    In "Lungs & Udders," Dr. Osterholm provides updates on H5N1 influenza, COVID-19, and mpox. He also shares his thoughts on a recent WHO report about airborne transmission and a study on the use of a diabetes drug to treat COVID-19. Airborne pathogens: controlling words won't control transmission by Greenhalgh et al., The Lancet (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00244-7/fulltext).
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    Episode 156: H5N1: An Impending Crisis?
    (2024-05-02) Dall, Chris; Osterholm, Michael
    In "H5N1: An Impending Crisis," Dr. Osterholm and Chris Dall discuss the spread of H5N1 avian influenza in US dairy cows, cover the latest COVID-19 trends, review two articles on long COVID, and answers a listener question about the safety of raw milk and other dairy products. Dr. Osterholm also shares a timely ""This Week in Public Health History"" segment and interviews the final two members of the podcast team. Early tests of H5N1 prevalence in milk suggest U.S. bird flu outbreak in cows is widespread, STAT (https://www.statnews.com/2024/04/25/h5n1-bird-flu-cows-outbreak-likely-widespread); Massive amounts of H5N1 vaccine would be needed if there's a bird flu pandemic. Can we make enough?, STAT (https://www.statnews.com/2024/04/24/h5n1-bird-flu-vaccine-preparedness/); Long-COVID patients more likely to report psychiatric symptoms, cost barriers to therapy, CIDRAP News (https://www.cidrap.umn.edu/covid-19/long-covid-patients-more-likely-report-psychiatric-symptoms-cost-barriers-therapy); The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China, Lancet Infectious Diseases (https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00171-3/fulltext).
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    Episode 155: Brighter Days Ahead
    (2024-04-18) Dall, Chris; Osterholm, Michael
    In "Brighter Days Ahead," Dr. Osterholm and Chris Dall discuss the latest national and international COVID trends, recent research on long COVID, and measles cases in the U.S. Dr. Osterholm also shares the latest ""This Week in Public Health History"" segment and interviews two members of the podcast team. Three studies spotlight long-term burden of COVID in US adults by Van Beusekom, CIDRAP News (https://www.cidrap.umn.edu/covid-19/three-studies-spotlight-long-term-burden-covid-us-adults); Lessons in persistence: new long COVID trials aim to clear lingering virus and help patients in dire need by Couzin-Frankel, Science (https://www.science.org/content/article/long-covid-trials-aim-clear-lingering-virus-help-patients-need); The pandemic's true death toll, The Economist (https://www.economist.com/graphic-detail/coronavirus-excess-deaths-estimates); Superbugs & You podcast (https://www.cidrap.umn.edu/antimicrobial-stewardship/superbugs-you).
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    Episode 154: H5N1 Uncertainty
    (2024-04-04) Dall, Chris; Osterholm, Michael
    "In ""H5N1 Uncertainty,"" Dr. Osterholm and Chris Dall discuss the latest national COVID trends, a recent study on Paxlovid, and H5N1 avian flu virus infection in cattle. Dr. Osterholm also shares the latest ""This Week in Public Health History"" segment and interviews two members of the podcast team. ""Swedish study suggests link between long COVID and severity of illness"" by Stephanie Soucheray, CIDRAP News (https://www.cidrap.umn.edu/covid-19/swedish-study-suggests-link-between-long-covid-and-severity-illness); ""Study: long COVID affects 8% of those with COVID-19, is more common in women"" by Stephanie Soucheray, CIDRAP News (https://www.cidrap.umn.edu/covid-19/study-long-covid-affects-8-those-covid-19-more-common-women); ""New neurologic issues less likely after severe COVID than flu, research suggests"" by Mary Van Beusekom, CIDRAP News (https://www.cidrap.umn.edu/covid-19/new-neurologic-issues-less-likely-after-severe-covid-flu-research-suggests); Nirmatrelvir for vaccinated or unvaccinated adult outpatients with COVID-19 by Hammond et al., New England Journal of Medicine (https://www.nejm.org/doi/full/10.1056/NEJMoa2309003); Treating acute COVID-19 — final chapters still unwritten by Gandhi & Hirsch, New England Journal of Medicine (https://www.nejm.org/doi/full/10.1056/NEJMe2402224).
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    Episode 153: Good News in a COVID-Indifferent World
    (2024-03-21) Dall, Chris; Osterholm, Michael
    In "Good News in a COVID-Indifferent World," Dr. Osterholm and Chris Dall discuss the national and international COVID trends, the latest research on long COVID, and antibiotic-resistant Shigella. Dr. Osterholm also shares the latest "This Week in Public Health History" segment and interviews members of the podcast team. "Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19" by Hanson et al., Nature Immunology (https://doi.org/10.1038/s41590-024-01754-8); "How Americans view the coronavirus, COVID-19 vaccines amid declining levels of concern" by Tyson & Pasquini, Pew Research Center (https://www.pewresearch.org/science/2024/03/07/how-americans-view-the-coronavirus-covid-19-vaccines-amid-declining-levels-of-concern/); "Spike in extensively drug-resistant Shigella cases reported in UK, Europe by Dall, CIDRAP News (https://www.cidrap.umn.edu/antimicrobial-stewardship/spike-extensively-drug-resistant-shigella-cases-reported-uk-europe); "CDC warns of increase in extensively drug-resistant shigellosis" by Dall, CIDRAP News (https://www.cidrap.umn.edu/antimicrobial-stewardship/cdc-warns-increase-extensively-drug-resistant-shigellosis); "Superbugs & You podcast" (https://www.cidrap.umn.edu/antimicrobial-stewardship/superbugs-you); "The man in the iron lung: by McRobbie, The Guardian (https://www.theguardian.com/society/2020/may/26/last-iron-lung-paul-alexander-polio-coronavirus).
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    Episode 152: A Tough Conversation
    (2024-03-07) Dall, Chris; Osterholm, Michael
    In "A Tough Conversation," Dr. Osterholm and Chris Dall discuss the new CDC COVID isolation guidelines, a measles outbreak in Florida, and the latest news on avian influenza. Dr. Osterholm also provides an update on influenza and RSV cases in the U.S. and shares the latest "This Week in Public Health History" segment. Background for CDC's Updated Respiratory Virus Guidance (https://www.cdc.gov/respiratory-viruses/background/index.html).
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    Episode 151: Harm Reduction
    (2024-02-22) Dall, Chris; Osterholm, Michael
    In this episode, Dr. Osterholm and Chris Dall discuss COVID isolation guidelines, the BA.2.87.1 variant, and the importance of measles and other rare public health threats. 
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    Episode 150: A Family Discussion
    (2024-02-08) Dall, Chris; Osterholm, Michael
    In "A Family Discussion," Dr. Osterholm and Chris Dall discuss the latest SARS-CoV-2 variant, consider the current and future challenges accessing Paxlovid, and explore new long COVID research. Dr. Osterholm also revisits last episode's discussion on changing public health guidelines and celebrates some canine heroes in the "This Week in Public Health History" segment. Resources: Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes, Yue Zhang, PNAS (https://www.pnas.org/doi/10.1073/pnas.2300644120); Minnesota hospitals say 65,000 days of care were avoidable if patients had somewhere to go, Jeremy Olson, Star Tribune (https://www.startribune.com/minnesota-hospitals-say-65000-days-of-care-were-avoidable-if-patients-had-somewhere-to-go/600340025/); Have a Paxlovid Prescription? Low Cost Options Available, Minnesota Department of Health (https://www.health.state.mn.us/diseases/coronavirus/paxrx.pdf); Find COVID-19 Medications, Administration for Strategic Preparedness and Response, HHS (https://treatments.hhs.gov/); Homeless man leaves puppies at N.C. shelter with heart-tugging note, Cathy Free, Washington Post (https://www.washingtonpost.com/lifestyle/2024/01/31/shelter-dog-rescue-homeless-fayetteville/).
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    Episode 141: One Huge Puzzle
    (2023-10-05) Osterholm, Michael; Dall, Chris
    In "One Huge Puzzle," Dr. Osterholm and Chris Dall discuss the state of the pandemic in the U.S. and around the world, the rollout of the updated mRNA vaccines, and two recently published studies on long COVID. Dr. Osterholm also shares his thoughts on the updated Novavax vaccine and answers an ID Query about COVID vaccine side effects. "A one-way ticket. A cash-stuffed teddy bear. A dream decades in the making," Carolyn Johnson, Washington Post (https://www.washingtonpost.com/health/2021/10/01/katalin-kariko-covid-vaccines/); "A scientific hunch. Then silence. Until the world needed a lifesaving vaccine," Carolyn Johnson, Washington Post (https://www.washingtonpost.com/science/2021/10/01/drew-weissman-mrna-vaccine/); "'A deadly societal force': A Q&A with author Dr. Peter Hotez on the anti-science movement," Mary Van Beusekom, CIDRAP News ) https://www.cidrap.umn.edu/anti-science/deadly-societal-force-qa-author-dr-peter-hotez-anti-science-movement); "Do you 'matter' to others? The answer could predict your mental health," Francine Russo, Scientific American (https://www.scientificamerican.com/article/do-you-matter-to-others-the-answer-could-predict-your-mental-health1/)
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    Episode 142: Long COVID, Intranasal Vaccines, & Booster Dose Timing
    (2023-10-19) Osterholm, Michael; Dall, Chris
    In this episode, Dr. Osterholm and Chris Dall discuss the latest national and international COVID trends, an intranasal COVID vaccine candidate, and some recent findings on long COVID. Dr. Osterholm also answers an ID Query about the timing of COVID booster doses and shares two historic public health moments in our new "This Week in Public Health History" segment.
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    Episode 77: A Booster Dose of Humility
    (2021-11-11) Osterholm, Michael; Dall, Chris
    In today's episode, Dr. Osterholm and Chris Dall discuss the surge of cases in Europe and what it could mean for the rest of the world, the importance of vaccinations and booster doses, COVID-19 cases in deer, and making Thanksgiving plans while remaining COVID-conscious. Evin's beautiful place (https://www.cidrap.umn.edu/evins-beautiful-place); listen to season 2 of Superbugs and You (https://link.chtbl.com/superbugs)
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    Episode 78: Breakthroughs and Boosters
    (2021-11-18) Osterholm, Michael; Dall, Chris
    In this episode, Dr. Osterholm explains what the rise in number of breakthrough infections really means, the importance of booster doses, and how to feel empowered to make a safe Thanksgiving decision based on personal and community risk. Mike's Beautiful Place (https://www.cidrap.umn.edu/mikes-beautiful-place-taiwan)
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    Episode 79: Thanksgiving Mini Episode
    (2021-11-24) Osterholm, Michael; Dall, Chris
    In this mini episode, Dr. Osterholm compares the dynamics of the pandemic this Thanksgiving to last year, and what factors to consider when making Thanksgiving plans.
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    Episode 80: The Emergence of Omicron
    (2021-12-02) Osterholm, Michael; Dall, Chris
    In "The Emergence of Omicron," Dr. Osterholm explains what we know and don't know about the Omicron variant, how we will learn more, and what it could mean for the future of the pandemic. Dr. Osterholm also emphasizes the importance of boosters and the potential for a post-Thanksgiving surge in cases. Micah's Beautiful Place (https://www.cidrap.umn.edu/micahs-beautiful-place)
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    Episode 143: Immunological Chess Match
    (2023-11-02) Osterholm, Michael; Dall, Chris
    In this episode, Dr. Osterholm and Chris Dall discuss national and international COVID trends, the low uptake in the latest COVID vaccine, and share thoughts about which infectious agents have pandemic potential. Dr. Osterholm also answers an ID query about influenza vaccination and shares a moment of joy from one of our listeners.
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    Episode 81: The Early Data on Omicron
    (2021-12-09) Osterholm, Michael; Dall, Chris
    In this episode, Dr. Osterholm analyzes the current data on transmission, disease severity, and ability to evade immune protection of the Omicron variant. We also discuss the continuing Delta surge in many parts of the world, the role of vaccines and boosters, and when booster doses may be available for 12-17 year olds. The Disappointed Tourist (http://www.disappointedtourist.org/)
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    Episode 82: A Viral Blizzard
    (2021-12-16) Osterholm, Michael; Dall, Chris
    In "A Viral Blizzard," Dr. Osterholm and host Chris Dall discuss the newest Omicron data, the crisis happening in hospitals across the US, the viral battle occurring between the Omicron and Delta variants, and the importance of booster doses. Sandra's Beautiful Place (https://www.cidrap.umn.edu/sandras-beautiful-place)
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    Episode 83: On Viral Time
    (2021-12-22) Osterholm, Michael; Dall, Chris
    In this week's episode, Dr. Osterholm and Chris Dall discuss the rapid global spread of the Omicron variant, how the United States and other countries around the world are responding to the Omicron surge, and how to approach the holidays. Last year's Polar Express Holiday Episode (cidrap.umn.edu/covid-19/podcasts-webinars/polar-express)
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    Episode 84: Imperfect Situations and Imperfect Solutions
    (2021-12-29) Osterholm, Michael; Dall, Chris
    In this week's episode, Dr. Osterholm and host Chris Dall discuss eight major issues surrounding the rapid spread of the Omicron variant and his stance on the new CDC quarantine and isolation guidelines.
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    Episode 85: Smart Testing in the Omicron Surge
    (2022-01-06) Osterholm, Michael; Dall, Chris
    In "Smart Testing in the Omicron Surge," Dr. Osterholm analyzes the data on the severity of the Omicron variant, the rise in hospitalizations, the effectiveness of rapid antigen tests, and the new testing strategies being implemented across the US.