Erin Malone

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Adrenergic, cholinergic and nonadrenergic-noncholinergic intrinsic innervation of the jejunum in horses
(American Veterinary Medical Association, 1999) Malone, Erin D; Kannan, Mathur S; Brown, David R; Turner, Tracy A; Trent, Ava M
OBJECTIVE: To determine the major neurotransmitters that regulate contractile activity in the jejunum of horses. SAMPLE POPULATION: Jejunal specimens from 65 horses without gastrointestinal tract lesions. PROCEDURE: Jejunal smooth muscle strips, oriented in the plane of the circular or longitudinal muscular layer, were suspended isometrically in muscle baths. Neurotransmitter release was induced by electrical field stimulation (EFS) delivered at 30 and 70 V intensities and at various frequencies on muscle strips maintained at low or high muscle tone. To detect residual nonadrenergic-noncholinergic neurotransmission, the response of muscle to EFS in the presence of adrenergic and cholinergic blockade was compared with the response in the presence of tetrodotoxin. RESULTS: Atropine (ATR) decreased the contractile response of muscle strips to EFS under most conditions. However, ATR increased the contractile response of high-tone circular muscle. Adrenergic blockade generally increased the muscle responses to 30 V EFS and in high-tone longitudinal muscle but decreased contractile responses in high-tone circular muscle. Tetrodotoxin significantly altered the responses to EFS, compared with adrenergic and cholinergic receptor blockade. CONCLUSIONS: Acetylcholine and norepinephrine appear to be important neurotransmitters regulating smooth muscle contractility in the equine jejunum. They induce contraction and relaxation, respectively, in most muscle preparations, although they may cause opposite effects under certain conditions. In addition, nonadrenergic-noncholinergic excitatory and inhibitory influences were detected. CLINICAL RELEVANCE: Acetylcholine or norepinephrine release within the myenteric plexus of horses may alter gastrointestinal motility.
Anaplastic sarcoma of the mandible in a llama
(The Canadian Veterinary Journal, 1996) Malone, Erin; Roertgen, Karen; Kobluk, Calvin
Bladder outlet obstruction in a 6-month-old alpaca secondary to pelvic displacement of the urinary bladder
(Canadian Veterinary Journal, 2005) McClanahan, Susan; Malone, Erin; Anderson, Kari
A 6-month-old female alpaca was presented for stranguria. Based on the history, physical examination findings, and radiographic studies, the alpaca was diagnosed with bladder outlet obstruction, secondary to pelvic displacement of the bladder, a condition previously unreported in camelids. Cystopexy was performed and the alpaca recovered unremarkably.
Blastomycotic osteomyelitis associated with severe lameness in a horse
(Canadian Veterinary Journal, 2011) Mendez-Angulo, Jose L; Swaab, Megan E; Malone, Erin; Olson, Erik J; Chalkley, Mark D; Aird, Betsy; Ward, Christie
A 12-year-old Quarter horse gelding was presented for evaluation of severe right forelimb lameness, 2 draining tracts over the lateral aspect of the right proximal antebrachium, and weight loss. A presumptive diagnosis of blastomycotic osteomyelitis was established based on radiographs and cytology of the exudate. This diagnosis was confirmed at necropsy.
Colic in your horse
(University of Minnesota Extension, 2018) Malone, Erin
Colic indicates a painful problem in your horse’s abdomen. Because colic is often unpredictable and frequently unpreventable, it’s a common concern for horse owners. Horses are naturally prone to colic. Fortunately, over 80 percent of colic types respond well to treatment on the farm.
Comparison of Veterinary Student Self-Perception of Comfort and Abilities in Independent Learning with Quality of Online/ Virtual Course and Student Performance
(Education in the Health Professions, 2023) Root Kustritz, Margaret V; Lashbaugh, Kristy D; Rendahl, Aaron K; Malone, Erin D; Larsen, Roxanne J; Burton, Erin N; Gordon-Evans, Wanda J
Background: Students expressed concern about having been forced to move toward more online or virtual learning starting in March 2020 with the coronavirus disease pandemic. Our hypotheses were the following: if a course is well designed, success in the course is not dependent on student comfort level. If a course is not well designed, student comfort level is a significant factor, and those students who are more comfortable with independent learning may outperform students who are less comfortable in courses offered virtually. Materials and Methods: Student performance, as demonstrated by examination scores, was compared with their comfort as independent learners and with the quality of online/virtual course offerings. Data analysis consisted of descriptive statistics and a linear mixed model. Results: Student performance was directly associated with comfort level, with those students who were less comfortable performing less well. Student discomfort with independent learning of online/virtual coursework could not be mitigated by increasing course quality in this study. Conclusions: Students may benefit from understanding what about independent learning makes them uncomfortable and directly addressing it. Instructors can do much to improve the learning experience in online courses by following published best practices. It may well be that many of the reported negatives of online learning will ease with time as students and instructors become more accustomed to independent learning paradigms.
COVID Bedfellows: Combining Clinical Skills and Anatomy Laboratories in the DVM Curriculum
(Education in the Health Professions, 2021) Malone, Erin D; Brown, Abby L; Spence, Susan J
Background: Prior to the fall of 2020, clinical skills and anatomy were considered separate courses with minimal overlap other than being offered to the same cohort of students. We had included clinical skills practice in anatomy labs on an intermittent and variable basis. Many of the skills were included only if time and faculty or staff availability permitted. The coronavirus disease 2019 (COVID- 19) pandemic made us think differently, particularly as the anatomy space was one of our largest rooms. Methods: Anatomy and clinical skills shared space and content during the 2020–2021 school year in an effort to meet physical distancing and other biosafety requirements required by the state and University. Results: Students were maintained in a single space and were engaged for a longer period of time, making their commute and biosafety steps worthwhile while simultaneously opening up other spaces for distanced teaching needs. The goal of one skill/day for motor skill learning was maintained despite a challenging laboratory teaching schedule. Certified veterinary technicians taught both the anatomy and the skills portion, showcasing the value of their training and freeing faculty for other responsibilities. Conclusion: This teaching and learning combination led to an enhanced understanding of procedurerelated anatomy; direct anatomy application to veterinary work; opportunities for recall, transfer, and supervised practice; and optimized staff and space utilization.
Creating a teaching technician team for support of veterinary student training laboratories
(Education in the Health Professions, 2022-09-09) Malone, Erin D; Brown, Abby L
Veterinary technicians play valuable roles in most veterinary colleges and have particular strengths in coaching new learners. We moved to a teaching technician ‘float team’ model to provide teaching support to core pre-clinical laboratories in our DVM (Doctor of Veterinary Medicine) curriculum. The teaching technician team model has enabled us to better utilize staff skill sets and training, created efficiencies and expanded support provided to core laboratory courses, provided skill development and advancement opportunities for team members, and improved our ability to recognize and mentor our teaching staff. This model also allowed us to effectively adjust to the rapidly changing structure and increased numbers of laboratories brought on by the COVID-19 pandemic without increasing numbers of staff involved in laboratory teaching.
Creation of a Metric for Faculty Effort in Teaching in the Veterinary Curriculum
(Journal of Veterinary Medical Education, 2014) Root Kustritz, M; Molgaard, L; Malone, E
A teaching-effort metric was generated using information from health sciences literature and self-reported data from faculty members. This metric was used to verify faculty effort based on teaching assignments, to equalize teaching between faculty members within disciplines, and to help faculty members understand the ramifications of new teaching opportunities on their overall effort.
Curriculum Review and Revision at the University of Minnesota College of Veterinary Medicine
(Journal of Veterinary Medical Education, 2017) Root Kustritz, Margaret V; Molgaard, Laura K; Malone, Erin
Curriculum review is an essential part of ongoing curriculum development, and is a mandate of the American Veterinary Medical Association Council on Education (AVMA COE), the accrediting body of all North American schools and colleges of veterinary medicine. This article describes the steps in curriculum review undertaken by the University of Minnesota College of Veterinary Medicine (UMN CVM) in response to this mandate from the COE and to a recommendation from a recent collegiate review that was part of a larger university-level strategic planning effort. The challenges of reviewing and revising the curriculum within a short time frame were met by appointing a dedicated curriculum review board and by engaging students and faculty groups, both as focus groups and as specific faculty work sections within disciplines. Faculty voting on the process was very valuable as it permitted the curriculum review board and faculty groups to move ahead knowing there was a process in place for reassessment if most faculty did not agree with recommendations. Consistent support from the dean of the college and other administrators was vital in helping maintain momentum for curriculum review.
Effects of intestinal ischemia on in vitro activity of adjacent jejunum in samples obtained from ponies
(American Journal of Veterinary Research, 2001) Malone, Erin D; Kannan, Mathur S
Objective—To determine whether intestinal ischemia would alter activity of the jejunum in vitro or alter staining characteristics for certain types of enteric neurotransmitters. Sample Population—Jejunal samples obtained from 10 ponies. Procedure—Jejunal samples were obtained from locations proximal and distal to an area of small intestine made ischemic for 60 minutes. A portion of each sample was stained to detect substance P-like immunoreactivity, cholinergic and adrenergic neurons, and nitric oxide synthase. Portions of the remaining samples were suspended in muscle baths. General activity patterns (frequency and amplitude of contraction), responses to neuronal depolarization induced by electrical field stimulation (EFS), and responses to 1 μM norepinephrine (NE) were compared with responses of a normal section of small intestine obtained prior to ischemic insult. Results—Staining patterns were not altered. Proximal and distal sections had evidence of decreased contractility, compared with the normal section. Contraction frequency also was decreased, and distal sections had lower contraction frequency than proximal sections. Relaxation responses were decreased in distal sections. Responses to NE differed significantly for distal and proximal sections, compared with normal sections. Conclusions and Clinical Relevance—Short-term ischemia can significantly affect adjacent bowel. Contractile and relaxation responses are impaired. Discrepancies in intestinal motility patterns and alterations in response to NE for sections proximal and distal to ischemic intestine could lead to clinical ileus or slowed transit of ingesta.
The efficacy of imiquimod 5% cream (Aldara) in the treatment of aural plaque in horses: a pilot open-label clinical trial
(Veterinary Dermatology, 2010) Torres, Sheila MF; Malone, Erin D; White, Stephen D; Koch, Sandra N; Watson, Johanna L
Aural plaques affect at least 22% of horses and can be asymptomatic or cause ear sensitivity. Immunohistochemical and electron microscopy studies have shown a strong association between aural plaques and papilloma virus. The purpose of this study was to investigate the efficacy of imiquimod 5% cream, an immune response modifier with potent antiviral activity, in the treatment of equine aural plaques. Twenty-one horses were enrolled and 16 completed the study. Imiquimod 5% cream was applied three times a week, every other week. When both ears were affected only the worst affected ear was treated. Adverse effects in all horses included marked local inflammation, exudation and thick crust formation at the site of treatment and the adjacent skin. Removal of the crust before treatment was painful and required sedation in most horses. Complete resolution of lesions was noted in all horses immediately post-treatment and the long-term resolution rate was 87.5%. Duration of therapy ranged from 1.5 to 8 months (median: 2.9 mean: 3.5). All horses were followed-up for 12–22 months after treatment was discontinued and only two horses had a recurrence of lesions. Clinical signs related to the aural plaques prior to treatment were reported in 11 of 16 (68.8%) horses and included resistance to touching the ears and bridling. Complete resolution of these signs was reported by the owners in all of the horses followedup for at least 12 months. In conclusion, the topical application of imiquimod 5% cream is an efficacious treatment for aural plaques in horses.
Efficacy of imiquimod 5% cream in the treatment of equine sarcoids: a pilot study
(Wiley Online Library, 2008-06-28) Nogueira, Sandra AF; Torres, Sheila MF; Malone, Erin D; Diaz, Sandra F; Jessen, Carl; Gilbert, Sophie
Imiquimod is an immune response modifier with potent antiviral and antitumour activity. The objective of this pilot study was to evaluate the efficacy of an imiquimod 5% cream (Aldara™: 3M, Saint Paul, MN, USA) as a topical treatment for equine sarcoids. Fifteen horses with a total of 19 tumours were enrolled, including mixed (7), fibroblastic (5), flat (3), verrucous (2), and nodular (2) types. Baseline data included history, physical examination, tumour location, measurement and digital photography. Imiquimod was applied by the owners three times a week until complete resolution of the tumour or 32 weeks, whichever occurred first. Tumours were measured and photographed every 4 weeks. Treatment efficacy was defined as 75% or greater reduction of tumour size by the end of the trial. Four sarcoids were withdrawn from the study. Twelve of the remaining 15 tumours (80%) showed more than 75% reduction in size and nine (60%) totally resolved between 8 and 32 weeks. The most common adverse effects of exudation, erythema, erosions, depigmentation and alopecia were limited to the tumour and adjacent areas. The results suggest that topical imiquimod is a therapeutic option for the treatment of equine sarcoids, although more detailed studies are required to corroborate these initial findings.
Evaluation of gastrointestinal activity patterns in healthy horses using B mode and Doppler ultrasonography
(Canadian Veterinary Journal, 2005) Mitchell, Colin F; Malone, Erin D; Sage, Abby M; Niksich, Katie
Healthy adult horses were examined by using transabdominal ultrasonography to quantitatively and qualitatively evaluate activity of the jejunum, cecum, and colon with B mode and Doppler techniques. Doppler ultrasound was used to assess jejunal peristaltic activity. Examinations were performed on multiple occasions under imposed colic evaluation conditions, including fasting, nasogastric intubation, and xylazine sedation. In fasted horses, jejunal visibility was increased and jejunal, cecal, and colonic activity was decreased. The stomach was displaced ventrally and was visualized ventral to the costochondral junction. Xylazine sedation in fed horses had minimal effects; however, in fasted horses, xylazine significantly decreased jejunal and cecal activity. Nasogastric intubation in fasted horses had no observable effects on activity, but moved the stomach dorsally. B mode and Doppler jejunal activity were strongly correlated. Prior feeding and sedation status need to be considered when interpreting the results of equine abdominal ultrasound examinations. Doppler techniques may be useful for assessing jejunal activity.
Evaluation of substance P as a neurotransmitter in the equine jejunum
(American Journal of Veterinary Research, 2000) Malone, Erin D; Kannan, Mathur S; Brown, David R
OBJECTIVE: To determine whether substance P (SP) functions as a neurotransmitter in equine jejunum. SAMPLE POPULATION: Samples of jejunum obtained from horses that did not have lesions in the gastrointestinal tract. PROCEDURE: Jejunal smooth muscle strips, oriented in the plane of the circular or longitudinal muscle, were suspended isometrically in muscle baths. Neurotransmitter release was induced by electrical field stimulation (EFS) delivered at 2 intensities (30 and 70 V) and various frequencies on muscle strips that were maintained at low tension or were under contraction. A neurokinin-1 receptor blocker (CP-96,345) was added to baths prior to EFS to interrupt SP neurotransmission. Additionally, direct effects of SP on muscle strips were evaluated, and SP-like immunoreactivity was localized in intestinal tissues, using indirect immunofluorescence testing. RESULTS: Substance P contracted circularly and longitudinally oriented muscle strips. Prior treatment with CP-96,345 altered muscle responses to SP and EFS, suggesting that SP was released from depolarized myenteric neurons. Depending on orientation of muscle strips and stimulation variables used, CP-96,345 increased or decreased the contractile response to EFS. Substance P-like immunoreactivity was detected in the myenteric plexus and circular muscle layers. CONCLUSIONS AND CLINICAL RELEVANCE: Substance P appears to function as a neurotransmitter in equine jejunum. It apparently modulates smooth muscle contractility, depending on preexisting conditions. Effects of SP may be altered in some forms of intestinal dysfunction. Altering SP neurotransmission in the jejunum may provide a therapeutic option for motility disorders of horses that are unresponsive to adrenergic and cholinergic drugs.
Evidence-Based Clinical Skills Teaching and Learning: What Do We Really Know?
(Journal of Veterinary Medical Education, 2019) Malone, Erin
The recent programmatic focus on skills development in veterinary medicine means that many programs are devoting increased time to formal clinical skills teaching. This expansion makes it essential that we use the time as effectively as possible. This review examines current practices and veterinary training principles using the broader lens. In many areas, current practices may be hindering learning. Proposed practices include using videos and discussions for pre-laboratory training, focusing on a single complex skill at a time, using more near-peer instructors rather than faculty, including assessments in each teaching or practice session, and encouraging supervised distributed practice by incorporating practice sessions into the formal curriculum. Ensuring mastery of a few core skills rather than exposure to many may be the new goal. Further research is urgently needed on block versus spiral curricula, optimum instructor-to-student ratios, learning and practice schedules, hours required for proficiency, and the benefits of exercise on motor skills learning.
How To Treat Navicular Bone Fractures
(AAEP, 1997) Turner, Tracy; Malone, Erin
Navicular bone fractures can be effectively treated by immobilizing the navicular bone with a heel elevation shoe. By gradually lowering the hoof angle back to normal over a 4-month period of time, soundness for the effected limb can be achieved
Identification of normal parameters for ultrasonographic examination of the equine large colon and cecum
(Canadian Veterinary Journal, 2007) Hendickson, EH; Malone, ED; Sage, AM
Six healthy horses were examined by using transabdominal ultrasonography, as described (1-3), to evaluate activity and size of the large colon and cecum at various locations. Using size and number of sacculations, activity patterns and contractile frequency; significant differences that would allow ultrasonographic identification of dorsal versus ventral colons, if they were displaced, were not found. The cecum had significantly greater activity than the colon, and a trend was seen towards smaller sacculations in the cecum than in the large colon
Identification of Student Lifestyle Characteristics Associated with Training Choices to Drive Targeted Admissions in Veterinary Medicine
(Education in the Health Professions, 2020) Root Kustritz, Margaret V; Malone, Erin; Rendahl, Aaron
Background: There is an identified need for practicing veterinarians with a focus on food animal work in the United States. Students at the University of Minnesota College of Veterinary Medicine track by species (food animal, equine, mixed, and small animal) or discipline (research) in the latter part of their training. Identification of life experiences that are associated with students choosing the food animal track would permit the college to better target admissions to meet societal needs. Aims and Objectives: To identify lifestyle characteristics and activities associated with choice of the food animal track and to evaluate how student choice of track varies across their training. Materials and Methods: Students from three consecutive classes were surveyed to identify factors influencing track choice. Fisher’s test was used to compare data and Clopper–Pearson “exact” confidence intervals computed. Results: Students who declared interest in the 1st year in small animal, equine, or food animal as a track were highly likely to choose that at their final track later in the curriculum. Eightyfive percent of students in a food animalfocused early admission track chose the food animal track; the remainder chose the mixed track with cattle as one of their species of interest. Students were more likely to choose the food animal track if their undergraduate major was animal science, if they grew up in a rural area, lived on a farm, were in 4H or were in Future Farmers of America, or had shown or worked horses or cattle, or shadowed a large animal veterinarian. Students valued mentoring from within the college and from outside veterinarians. Conclusions: Knowledge of how students choose their tracks will permit the college better to promote admissions of students who are more likely to track food animal and to plan for adequate clinical year experiences for all students.
Improving Response Rates for Course and Instructor Evaluations Using a Global Approach
(Wolters Kluwer ‑ Medknow, 2018-10) Malone, Erin; Root Kustritz, Margaret; Molgaard, Laura
Obtaining sufficient survey responses to make course and instructor evaluation results meaningful is a challenge in many, if not most, health professions training programs. This paper describes a series of policy changes that significantly improved data quality at one college of veterinary medicine located in the United States. The steps consisted of minimizing the number of items appearing on the instruments, providing students adequate time and space for completion, clearly explaining the purpose and value of the evaluations, simplifying data collection, collecting verbal feedback, and closing the loop with student participants by informing them of any changes that were made as a result of their feedback. The steps outlined in this model may be easily extended to other health professions programs that involve cohort models, multi‑instructor courses and limited resources with respect to time and people.