Browsing by Subject "epilepsy"

Now showing 1 - 3 of 3
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    Long-range inhibition in the healthy and epileptic hippocampus
    (2019-08) Christenson Wick, Zoé
    There are many sources of inhibition and excitation that are carefully, and crucially, balanced within the brain. When this balance is off, pathological neuronal activity can emerge and lead to diseases such as epilepsy. My research identifies unique sources of inhibition in the hippocampus that are particularly interesting in the context of healthy hippocampal functioning as well as for temporal lobe epilepsy. Specifically, my dissertation has focused on two inhibitory neuron populations: one which has previously been shown to suppress seizures in a rodent model of chronic temporal lobe epilepsy, the other a previously uncharacterized and novel source of inhibition to the hippocampus that has several unique and surprising characteristics.
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    Out-of-Hospital Status Epilepticus and Use of Benzodiazepines
    (2009-05-06) Yang, Tou Cher
    Benzodiazepines are considered safe and effective in treatment of status epilepticus occurring in out-of hospital settings when administered by paramedics. Status epilepticus is defined here as seizure activity for greater than five minutes. Lorazepam is the recommended agent.
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    Site-Specific Hippocampal Modulation In Disease And Health: Temporal Lobe Epilepsy And Cerebello-Hippocampal Influence
    (2020-08) Zeidler, Zachary
    Like other areas of the brain, the hippocampus is finely tuned to receive information, transform it, and output the result. Unlike other areas of the brain, the hippocampus is a critical player for many cognitive processes, including spatial memory. When aberrant modulation of the hippocampus occurs, it can be manifested neurally, in the activity of the hippocampus itself, as well as behaviorally, through impaired hippocampal-dependent behaviors. My research examines two distinct forms of hippocampal modulation. The first: chronic temporal lobe epilepsy induced via a targeted, focal intrahippocampal insult in either the dorsal or ventral hippocampus. The second: indirect modulation of the hippocampus from stimulation of the medial or lateral cerebellar cortex. Both forms of modulation create broad yet specific changes to hippocampal activity and hippocampal dependent behavior. Interestingly, site-specificity with regard to both hippocampal and cerebellar targeting reveal overlapping yet distinct effects in their respective forms of hippocampal modulation. Together, my research advances the epilepsy field's ability to model particular temporal lobe epilepsy phenotypes, as well as our understanding of how cerebellar modulation affects hippocampal function.