Browsing by Subject "Streptococcus mutans"

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    An Oxymetazoline-based Nasal Solution Removes Bacteria-Blood Debris on Dental Surfaces and Has Antimicrobial Activity toward Streptococcus mutans Data Sharing Archive
    (2025-01-30) Jones, Robert S; Kumar, Dhiraj; Pride, Morgan; rsjones@umn.edu; Jones, Robert; B-A-M (Biofilm-Apatite-Microbiome) Lab; School of Dentistry
    Data used in the manuscript An Oxymetazoline-based Nasal Solution Removes Bacteria-Blood Debris on Dental Surfaces and Has Antimicrobial Activity toward Streptococcus mutans Background: An over-the-counter vasoconstrictive nasal solution with oxymetazoline (NS-OXY, 0.05%) has potential to be used as a dental pulpal hemostatic medicament. A molecular engineering approach examined NS-OXY and its molecular constituent’s an-timicrobial and blood biomass removal efficacy. Methods: An ex vivo cavity model was developed where standardized prepared teeth were exposed overnight to a model dentinal caries pathogen, S. mutans, and then exposed to Sheep’s blood for 10 minutes, which sim-ulated a pulpal exposure. Cavity preparations were rinsed with OXY (0.05%), ben-zalkonium chloride (BKC-0.025%), NS-OXY (with OXY-0.05% and BKC), ferric sulfate (20%;ViscoStat, FS), and distilled water (DI). For examining the bactericidal effect of NS-OXY, a disc diffusion antimicrobial assay was used where S. mutans was grown (20-hrs) on brain-heart infusion (BHI) w/0.5% glucose agar plates and exposed to the treatment groups. Results: NS-OXY treated samples had a lower residual bacterial or blood biomass than FS (P=.003). The diffusion test showed that NS-OXY, BKC, and FS had zones of inhibition greater than 10 mm, with NS-OXY having higher activity against S. mutans than FS (P=.0002) but lower than BKC (P=0.0082). Conclusions: NS-OXY may con-sidered as a dental hemostatic agent after traumatic and carious pulpal exposure owing to NS-OXY’s antimicrobial and vasoconstrictive properties.
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    A Novel Methacrylate Derivative Polymer That Resists Bacterial Cell-Mediated Biodegradation Data Sharing Archive
    (2021-11-22) Kumar, Dhiraj; Ghose, Debarati; Mutreja, Isha; Bolskar, Robert D.; Jones, Robert S.; rsjones@umn.edu; Jones, Robert S; B-A-M (Biofilm-Apatite-Microbiome) Lab; TDA Research, Inc.; School of Dentistry
    We studied biodegradation resistance of a custom synthesized (by TDA Research Inc) novel ethylene glycol ethyl methacrylate (EGEMA) with ester bond linkages that are external to the central polymer backbone when polymerized. Experiments were designed to compare degradation resistance with Ethylene glycol dimethacrylate (EGDMA) with internal ester bond linkages. The data has been published in an article titled "A Novel Methacrylate Derivative Polymer That Resists Bacterial Cell-Mediated Biodegradation" in the Journal of Biomedical Materials Research: Part B - Applied Biomaterials. The data in this record supports the figures in the published manuscript.