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Browsing by Subject "Department of Pharmaceutics"

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    Preparation of Gold-coated Magnetic Nanorods for Lung Cancer Treatment
    (2012-04-18) Fakhoury, Joanna
    Gold-coated magnetic nanorods are a possible means for achieving selective destruction of lung cancer cells through plasmon resonance. These particles can be delivered to the lung by inhalation and can be detected by the non-invasive imaging technique of magnetic resonance imaging (MRI). In this study, experimental methods were evaluated for the preparation gold coated nanorods. Iron chloride salts, FeCl2 or FeSO4, were dissolved and then precipitated with base. Ammonium or potassium nitrate was added to oxidize the precipitated ferrous oxides along with various polyethylene glycols to yield selective magnetite particles (Fe3O4) with needle-like morphology. The magnetic nanorods were recovered and coated with gold by adding the mild reducing agent, hydroxylamine, in the presence of tetrachloroaurate (HAuCl4). The thickness of the gold layer can be controlled by the particle concentration and amount of gold added. The particles are then characterized in terms of composition, size, shape, induced magnetization and light absorption.