University of Minnesota Libraries Publishing
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Item From Digitalis to Ziagen: The University of Minnesota's Department of Medicinal Chemistry(University of Minnesota Libraries Publishing, 2012) Abul-Hajj, Yusuf J.; Broderick, RichardA comprehensive history of Medicinal Chemistry beginning with the founding of the University of Minnesota’s College of Pharmacy in 1892 until today. In turn that same period of time—1892 to 2012—also represents the most revolutionary era in the history of the entire discipline of medicinal chemistry, witnessing the transformation of the field from an artisanal, trial-and-error approach to isolating and testing therapeutic elements in natural elements to today’s high-tech, computer-assisted discovery and design of new, targeted drugs.Item Ong for Everybody: An Introduction to Walter J. Ong's Groundbreaking Technology Thesis and an Annotated Classified Bibliography of Selected Related Works(University of Minnesota Libraries Publishing, 2014) Farrell, Thomas, JThomas J. Farrell is a professor Emeritus in the Department of Writing Studies at the University of Minnesota Duluth. Ong for Everybody includes an accessible introduction and annotations to the works of Walter J. Ong, S.J. (1912-2003), an American cultural historian and philosopher.Item Nostalgia: Sanctuary of Meaning(University of Minnesota Libraries Publishing, 2014) Wilson, Janelle LIn writing this book, Dr. Janelle L Wilson, Professor in the Department of Sociology/Anthropology at the University of Minnesota Duluth, explores the concept (and experience) of nostalgia. This work brings together research Dr. Wilson carried out over the past several years. In writing the book, she hopes to place the body of research in a framework, make meaning of it, and share it with you, the reader. Dr. Wilson challenges readers to think about their own experience of nostalgia and how it may (or may not) fit with the ideas presented here.Item Open Rivers, Issue One: Fall 2015(University of Minnesota Libraries Publishing, 2015-11)Item Open Rivers, Issue Two: Spring 2016(University of Minnesota Libraries Publishing, 2016-02)Open Rivers, Issue Two. An interdisciplinary journal about the Mississippi River as a space for critical conversations about people, community, water, and place.Item Impact of Pharmacist-Delivered Patient Education on Tuberculosis Drug Therapy Adherence(University of Minnesota Libraries Publishing, 2017-06) Schmitz, Dylan M.; Fleissner, Dan; Tran, AmyTreatment of tuberculosis poses unique clinical challenges that make successful completion of treat- ment traditionally low compared with other infectious diseases. Specifically, patient adherence to the long medication regimen is crucial for the success of treatment. Are pharmacists, the medications experts, being optimized with their clinical knowledge to assist in the management of tuberculosis treatment and does their impact provide a benefit to the patient? In order to determine the pharmacists impact on adherence to therapy for tuberculosis treatment, a systematic literature review utilizing OVID Medline was conducted. A search term criteria was formulated then used to generate literature pertaining to the clinical question. The initial search resulted in 21 hits, which were subsequently screened using the predetermined exclusion and inclusion criteria. Of the 21 initial results 17 were excluded from the review. The included studies demonstrated positive impact pharmacists had on the adherence and completion of prescribed tuberculosis medications. This trend presents an opportunity for pharmacists to provide clinical services that utilize their strength and ensure positive therapeutic outcomes for patients. Al- though the findings are encouraging, the included studies have drawbacks that while addressed, present the direction for future study.Item The Benefits of Raloxifene Use in Postmenopausal Women with Alzheimer’s Disease(University of Minnesota Libraries Publishing, 2017-06) Sobota, SaraThis qualitative systematic review aims to compile evidence to assess potential cognitive benefit with raloxifene use in postmenopausal women with Alzheimers disease. PubMed, EMBASE, and Cochrane Library databases were searched using the terms raloxifene, Evista, postmenopausal, Alzheimers, demen- tia, cognitive, and cognition. Reviewed studies were limited to human subjects written in the English language between 2002 and January 2017. Of 36 studies, only four articles were included in the as- sessment. The most reliable results come from the MORE trial which describes a dose-dependent (120 mg/day) reduction in cognitive impairment and lower risk of developing Alzheimers disease after three years of raloxifene use in postmenopausal women who were considered cognitively normal at baseline. The other three articles reviewed in this study showed no significant cognitive benefit associated with raloxifene treatment. However, all three of these studies showed high potential for bias based on this review of the cognitive assessment method, intervention, study duration, and population. Two of these three studies utilized a dose that was too low (60 mg/day) in cognitively normal women. The third study showing bias had the smallest total population (n=42) but it used an appropriate dose of 120 mg/day and it was the only study to include participants with an established diagnosis of Alzheimers disease. Based on the results of this database search and analysis, there appears to be insufficient available liter- ature that includes an appropriate raloxifene dose, study duration, assessment method, and population. This suggests justification for future clinical trials to properly evaluate the potential cognitive benefit of raloxifene in postmenopausal women with Alzheimers disease.Item Adherence to Drug Therapies in TB/HIV Patients: A Systematic Review of Fixed Dosed Combination Drug Therapy vs. Directly Observed Therapy(University of Minnesota Libraries Publishing, 2017-06) Nguyen, Larry; Vazquez-Deida, Axel A.; Chak, Veasna M.The objective of this paper was to discern if there was a difference in adherence between fixed dose combination drug therapy (FDCT) and directly observed therapy (DOT) when treating patients with both tuberculosis (TB) and human immunodeficiency virus (HIV). Various search terms were used resulting in 1,646 related articles. 1,637 articles were eliminated using further screening and elimination criteria. A total of 8 peer-reviewed publications and reports classified either as primary or secondary were used for data extraction. These articles studied HIV/TB patients receiving either FDCT or DOT and included extractable data on the number of non-adherent patients versus total number of patients for their respective therapy. Information obtained during data extraction included: article definition of adherence, reasons for non-adherence, number of patients in the trial, and number of patients adherent to therapy. The results showed 70.2% of patients were adherent to directly observed therapy, and 92.5% of patients were adherent to fixed dosed combination drug therapy. This paper concluded that patients are more adherent to FDCT than DOT.Item Opioid Use In Pregnant Women and its Effect on the Development of Neonatal Abstinence Syndrome in Newborns(University of Minnesota Libraries Publishing, 2017-06) Qiao Yang, Yue; Ding, VikiThe current guidelines for chronic noncancer pain management by the American Pain Society rec- ommends opioids as the therapeutic choice to lessen pain and/or recover physical and psychological functioning. However, misuse of opioids during pregnancy has become an alarming concern across the United States impacting the health of both the mother and newborn. Infants experiencing opioid with- drawal symptoms, also known as neonatal abstinence syndrome (NAS), are at higher morbidity risk and other long-term developmental risks that are yet to be understood. In this review, five quality studies were assessed and analyzed to make recommendations on methadone and morphine-derivative opioid use for chronic pain management in pregnant women. Methadone has proven to be an effective option for moderate to severe pain and relatively safer than other opioid choices if prescribed at a reduced dose of 30 mg daily for 7 weeks. Codeine can be selected for mild to moderate chronic pain management and should not exceed 60 mg every 4 hours for patients in the third trimester. However, it is inferior for pain relief compared to morphine, whereas methadone is comparable. Both dosing recommendations are expected to have decreased risk of NAS development compared to dosing used in literature.Item Pharmacy Services in Telepharmacy: how’s it working, where it’s working, and what’s required to practice in this new setting.(University of Minnesota Libraries Publishing, 2017-06) Skrei, Aimee; Rundquist, Michelle M.Telepharmacy is a rapidly growing area of communication within pharmaceutical care delivery, es- pecially in rural areas. The purpose of this literature review was to determine where telepharmacy is currently being practiced within community and ambulatory pharmacy settings and the effectiveness of it. Additionally, state rules and regulations for the upper Midwest region were compared and con- trasted to analyze how specific states are addressing the use of telepharmacy practice within the specified settings. A systematic literature review was performed using PubMed, Ovid Medline, and the Google Scholar search engine. State specific rules were researched using board of pharmacy and legislative online resources. Overall, telepharmacy was found to be an effective and safe delivery method to communi- cate with patients regarding their medications. It has been successfully implemented within community pharmacy settings through the creation of remote dispensing sites, which is evident through literature analysis. The focus of state regulations on telepharmacy services and practices shows the growth and ac- ceptance of this modality of pharmacy practice. There is wide variation among Midwest state regulations pertaining to the setup and operation of telepharmacies. Trends in telemedicine show that telepharma- ceutical care is likely to continue to expand as it allows for a better allocation of resources and access to more patients. Further primary research needs to be completed to specifically analyze telepharmacy cost-effectiveness.Item An Investigation Into the Evidence Behind Budesonide/Formoterol (Symbicort®) Usage in the Outpatient Setting as Reliever Medication for Asthma(University of Minnesota Libraries Publishing, 2017-06) Walek, Stephanie; McDonald, Ashley; Wolff, RobertObjective: To review the available scientific evidence behind the use of budesonide/formoterol for maintenance and reliever therapy for the outpatient control of asthma exacerbation. Data sources: The Medline database was searched using the terms albuterol, asthma, budesonide for- moterol fumarate drug combination, exacerbation, formoterol fumarate, guidelines, long acting beta 2 agonist, randomized control trial, reliever, and Symbicort. Articles cited in the 2016 GINA guidelines were also assessed for relevance and included in this literature review. Methods: Studies evaluating the clinical efficacy of budesonide/formoterol for maintenance and reliever therapy in patients ≥ 12 years old with diagnosed asthma were included. Acceptable study designs included RCTs, retrospective analyses, prospective analyses, and post hoc analyses published in English no earlier than 2002. All titles and abstracts were initially reviewed for relevance. Articles remaining after initial review were divided equally among authors for in-depth review and data extraction. The quality of evidence of each study was assessed using the 2011 Oxford Levels of Evidence table. Results: Fourteen of the nineteen articles supported using budesonide/formoterol as both a reliever and maintenance medication. Four articles found no difference in time to first severe asthma exacerbation and one article found no significant difference in number of asthma control days. Conclusions: The evidence of this review supports the use of budesonide/formoterol as both a mainte- nance and reliever therapy in adults with uncontrolled, persistent asthma. SMART (Single Maintenance and Reliever Therapy) improves a number of asthma control measures, deeming it a favorable option for inclusion in future NHLBI guideline revisionsItem Effects of Tacrolimus Pharmacokinetic Variability on Acute Rejection and Long-Term Graft Function after Kidney Transplantation(University of Minnesota Libraries Publishing, 2017-06) Seibert, StephanTacrolimus (TAC) is used for immunosuppression after kidney transplantation. Non-optimal TAC therapy contributes to renal toxicity, graft damage, and rejection. This paper reviews publications associating TAC intra-patient pharmacokinetic variability with long- and short-term transplant outcomes. The literature was reviewed performing systematic searches of MEDLINE and EMBASE databases from 1990 to May 2016 using appropriate Medical Subject Headings (MeSH) and key words. Titles and abstracts of hits were scanned for relevance, resulting in nine articles included in this analysis. Included articles were evaluated for content and relevance, and summarized. All studies were relatively small (N <400) non-randomized retrospective chart reviews. Only two articles did not show significant association between variability of TAC trough concentrations and at least one outcome after kidney transplantation. Four studies analyzing acute rejection (AR) showed significant association, while two did not. All studies analyzing graft loss or composite outcomes including graft loss showed significant association. Other studies showed association with donor-specific-antibody (DSA) development, but no association with renal function decline or overall patient survival. This review indicates an overall trend towards worse transplant outcomes in patients with higher TAC pharmacokinetic variability, however the size and design of the studies limit generalizability. Larger studies with more robust design are needed and should include genetic subgroup analysis and identification of sources of TAC variability to come to a definitive conclusion. Ideally, a dosing protocol incorporating wide varieties of genetic and clinical factors should be developed to optimize TAC dosing in transplant patients.Item Smoking and its effects on postpartum depression.(University of Minnesota Libraries Publishing, 2017-06) Swanson, Elizabeth; Scott, Elizabeth; Thomas, MeredithAn estimated 10 to 15% of new mothers experience symptoms of postpartum depression (PPD), and while it has been estimated that up to 10% of women smoke tobacco during the last 3 months of pregnancy(1), there has been limited research into the effects this behavior has on the development of PPD. To establish if a relationship exists between the two, a literature search of published research studies was completed to gather data for examination. Of the pertinent articles, there were 11 that supported an association between smoking before or during pregnancy and postpartum depression, and the results of these were examined in depth. All studies found some sort of correlation, however not all findings were statistically significant. One of the biggest remaining questions is that of the causality between the relationship. No one has yet been able to establish whether postpartum depression is caused by smoking at any point during a mothers lifetime, or whether having depression is a risk factor for continued smoking.Item Comparing the effects of transdermal hormone therapy to oral hormone therapy on gallbladder disease, cholecystectomy, and gallbladder cancer(University of Minnesota Libraries Publishing, 2017-06-30) Hersi, Faid; Onwonga, Esther B.; Horst, JennaObjective: To determine whether transdermal hormone therapy produces less effects on the development of gallbladder disease and cancer than oral hormone therapy. Data sources: OVID, PubMed, Medline, and NIH Study selection: Studies that included women who are 40 -75 years of age who were naive to hormone therapy. Studies chosen had to include both transdermal and oral routes of hormone administration as well as findings related to gallbladder disease, cancer, or markers that affect these conditions. Reviews were not included in our study criteria. The primary outcome was incidence of gallbladder disease and cholecystectomy. Data synthesis: Of the 98 articles, 5 articles were included in the assessment. 2 studies assessed gallbladder disease/cholecystectomy, 2 assessed biomarkers for gallbladder stone, and 1 assessed gallbladder disease as a risk for gallbladder cancer. Prospective data suggests that transdermal hormone therapy has a lower risk of gallbladder disease and cholecystectomy. Evidence also suggests a positive correlation between gallbladder disease and gallbladder cancer. Conclusions: The preliminary evidence suggests that transdermal hormone therapy has a lower risk of gallbladder cancer. There is a strong association between gallbladder cancer and cholelithiasis, chronic cholecystitis, and inflammation. Based on the evidence, transdermal therapy may have a lower risk of gallbladder disease and cholecystectomy. In addition, transdermal has a more favorable lipid panel. The evidence also suggests some correlation between hypercholesterolemia and risk of cholecystectomy.Item A How-to Manual for the Graduate Review and Improvement Process(University of Minnesota Libraries Publishing, 2017-09) Hakkola, Leah; Moon, Doug; Ginger, MichelleThe inaugural volume of the Minnesota Evaluation Studies Institute (MESI) Program Evaluation Series features the Graduate Review and Improvement Process (GRIP). GRIP is an innovative student-centered process designed to develop actionable steps to enhance student success in graduate programs. MESI staff, primarily graduate students in the Evaluation Studies program, developed and implemented the process in consultation with the University of Minnesota Graduate School as an alternative to the traditional University external review process that typically occurs every five to ten years and produces largely quantitative information about a program (for example, time to degree, retention, and number of publications). With its commitment to active student involvement in the evaluation, GRIP can serve as a complementary process to external monitoring and surveying, one that allows students and program leaders to assess the quality of their curriculum, advising, instruction, and related services and to devise realistic plans to improve them.Item A Field Guide to Ripple Effects Mapping(University of Minnesota Libraries Publishing, 2017-10) Chazdon, Scott; Emery, Mary; Hansen, Debra; Higgins, Lorie; Sero, RebeccaThe second volume in the Minnesota Evaluation Studies Institute Program Evaluation Series focuses on the emerging evaluation technique of Ripple Effects Mapping (REM). This participatory data collection method is designed to capture the impact of complex programs and collaborative processes. Well-suited for evaluating group-focused efforts, Ripple Effects Mapping involves aspects of Appreciative Inquiry, mind mapping, facilitated discussion, and qualitative data analysis. As the REM process unfolds, the intended and unintended impacts of participant efforts are visually displayed in a way that encourages discussion and engagement. Using these visuals, plus other graphics, pictures, and real-life examples of how Ripple Effects Mapping has been successfully used in multiple settings, this book provides a comprehensive overview of REM. Providing an in-depth examination of the origins, elements, and how-to of the REM process, the Field Guide to Ripple Effects Mapping is a step by-step guide to successfully implementing this process with a group, collaboration, or community of choice.Item Innovative Learning and Teaching: Experiments Across the Disciplines(University of Minnesota Libraries Publishing, 2017-11) Alexander, Ilene D.; Poch, Robert K.The authors collected in Innovations in Learning and Teaching are faculty and instructors from various University of Minnesota campuses, each part of a team that successfully completed university-funded grant projects with teaching and technology consultants. Here, several faculty extend the conversation through scholarship of learning and teaching articles. Readers, including future faculty, as well as current instructors, faculty, administrators, regents and legislators, will benefit from the authors’ attention to learners, complex learning, practicable pedagogy, and curricular experimentation.Item An Introduction to Cooperation and Mutualism(University of Minnesota Libraries Publishing, 2017-12) Boland, MichaelThis textbook introduces readers to the idea of cooperation and mutualism. Cooperatives and mutuals are participatory organizations in which members participate in control and governance, receive economic benefits through patronage refunds or net income, and become owners through equity. These mutual-benefit organizations exist alongside non-profit organizations and investor-benefit organizations through the global economy.Item Otolaryngology at the University of Minnesota: 1888-2018(University of Minnesota Libraries Publishing, 2018-09) Wilson, KentOtolaryngology at the University of Minnesota: 1888–2018 is an engaging story of the 130-year development of the medical specialty at the University of Minnesota. This book covers the program’s early days in a near-frontier setting, to its rise in becoming a regional and national leader of research and specialty medical education. Editor Kent Wilson, MD, walks readers through the program’s early history, from the first Professor of Eye & Ear, John F. Fulton, MD, PhD, to current development of advanced fellowship training in Facial Plastic & Reconstructive Surgery, Pediatric Otolaryngology, and Neurotology. All in all this book provides a contemporary look at otolaryngology — past, present, and future.Item 2018 Directory of Evaluator Education Programs in the United States(University of Minnesota Libraries Publishing, 2018-10) LaVelle, John M.The 2018 directory of evaluator education programs in the United States, complete with all available curricular information, organized by location, and with an introduction on applying to graduate programs in evaluation.