Browsing by Author "DesLauriers, Nicholas"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Ion Channel Activity of Muscle Regulatory Proteins Sarcolipin and Phospholamban
    (2012-04-18) DesLauriers, Nicholas
    The proposed research will investigate the role of two key proteins, sarcolipin (SLN) and phospholamban (PLB), in muscle contractility. Both SLN and PLB monomers have a primary regulatory function of inhibiting calcium (Ca) transport of the sarcoplasmic reticulum Ca-ATPase (SERCA). SLN inhibits SERCA in skeletal muscle, while PLB inhibits SERCA in cardiac muscle. Adrenaline phosphorylates SLN and PLB, reversing SERCA inhibition and stimulating muscle contraction. This research project will examine a potential second function of SLN and PLB: the formation of ion transport channels.