Browsing by Author "Bueno, Irene"

Now showing 1 - 9 of 9
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    Determination of the antibiotic and antibiotic resistance footprint in surface water environment of a metropolitan area: Effects of anthropogenic activities
    (2022-09-26) He, Huan; Bueno, Irene; Kim, Taegyu; Wammer, Kristine H.; LaPara, Timothy M.; Singer, Randall S.; Beaudoin, Amanda; Arnold, William A.; heh@umn.edu; He, Huan; University of Minnesota Department of Civil, Environmental, and Geo- Engineering; University of Minnesota Department of Veterinary and Biomedical Sciences; University of St Thomas Department of Chemistry; Minnesota Department of Health
    This study investigated geospatial distributions of antibiotics and antibiotic resistance genes (ARGs) in surface waters and their associations with anthropogenic activities. During July‒October 2020, the concentrations of antibiotics (water and sediment) and ARGs (sediment) were measured at 39 sites in the Twin Cities metropolitan area (Minnesota) that experience a gradient of impacts related to human activities. For water samples, the number of antibiotics detected and the concentrations of certain antibiotics (e.g., sulfonamides) positively correlated with urbanization indicators (e.g., urban percentage, population density, number of wastewater discharge points; ρ =0.32‒0.46, p =0.003‒0.04) and negatively correlated with undeveloped land indicators (e.g., forest; ρ =-0.34‒-0.62, p =<0.00001‒0.04). Antibiotics in sediments exhibited geospatial distribution different from that in corresponding water samples and exhibited no associations with anthropogenic factors. Relative abundances of ARGs were not associated with anthropogenic factors, but several ARGs (e.g., blaoxa, mexB, and sul2) were inversely related to the organic content of sediments (ρ =-0.38‒-0.44, p =0.01‒0.04). Strong correlations were found among relative abundances of various ARGs and intI1 (ρ ≥ 0.67, p < 0.05), highlighting their co-occurrence in (sub)urban surface waters. These results identified promising anthropogenic/environmental factors for predicting antibiotic geospatial distributions and useful gene markers to monitor ARGs in surface waters.
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    E-supplement to: Efficacy of antibiotic and non-antibiotic interventions in preventing and treating necrotic enteritis in broiler chickens: a systematic review
    (2022) Bueno, Irene; Ricke, Isabel; Hwan, Haejin; Smith, Emily; Nault, Andre; Johnson, Timothy; Singer, Randall S.
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    Efficacy of antibiotic and non-antibiotic interventions in preventing and treating necrotic enteritis in broiler chickens: a protocol for a systematic review
    (2020) Bueno, Irene; Smith, Emily; Hwang, Haejin; Nault, Andre J.; Valeris-Chacin, Robert; Singer, Randall S.
    Necrotic enteritis is one of the most common and economically important bacterial diseases affecting the broiler industry. Limitations on the use of antimicrobials have highlighted the need to evaluate the efficacy of non-antibiotic alternatives and management strategies. However, the available evidence on the efficacy of non-antibiotic interventions for necrotic enteritis has not been systematically synthesized. Here we present a protocol to conduct a systematic review of the literature to assess the efficacy of non-antibiotic interventions compared to antibiotic interventions in preventing and treating necrotic enteritis cases in broiler chickens.
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    Monitoring the spatiotemporal patterns of wildlife health using rehabilitation databases
    (2022-04-07) Kanankege, Kaushi; Willette, Michelle; Jenni, Phil; Ponder, Julia; Schott, Renee; Bueno, Irene; Muellner, Ulrich; Muellner, Petra; VanderWaal, Kimberly; kanan009@umn.edu; Kanankege, Kaushi; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota
    Wildlife health surveillance is challenging. An alternative is to use wildlife rehabilitation data as potential sentinels, where anomalies in the pattern of submissions may indicate an underlying event that deviates from the baseline and warrants further investigation. Such anomalies may affect multiple species, leading submissions to be clustered in a certain area or time period. To determine spatiotemporal submission patterns and the feasibility of identifying anomalies potentially associated with underlying events, we aggregated databases from two major wildlife rehabilitation centers in Minnesota, drawing on 66,472 submissions from the 2015 – 2019 period, and pertaining to 29 ”species groups” and 12 “circumstances” associated with submission. The infants and juveniles of wildlife, including fledglings, hatchlings, and after-hatch year birds (raptor-specific), submitted as a group from the same location on the same day were grouped and considered as one submission. Hence, the number of records included in the spatiotemporal cluster analysis was 49,352. The multivariate multinomial space-time model of the scan statistic was used to identify statistically significant spatiotemporal clusters of either wildlife species groups or circumstances, simultaneously (Cluster: an area capturing 10% of the submissions aggregated within a maximum radius of 30km during a maximum temporal window of 3-months). This repository contains the data arranged to be used for the spatial cluster analysis.
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    Persistence of Antibiotics in the Natural Environment: Scoping Review Protocol
    (2021) Bueno, Irene; He, Huan; Nault, Andre J.; Ziemann, Sarah; Degn, Lauren; Arnold, William A.; Wammer, Kristine H.
    Background: Antibiotics and their metabolites released into aquatic and soil environments have the potential to affect their microbial communities and can be a selection pressure to drive antimicrobial resistance emergence and spread. However, data about the persistence of antibiotics and metabolites into the natural environment are still lacking. Objectives: The goal of this manuscript is to describe the protocol that will be used to conduct a formal scoping review of the current literature to address the following question: “What is known from the existing literature about degradation of a selected group of antibiotic compounds in water, sediment, and soil?”. Eligibility criteria: Eligible studies will be primary research, in English, from any geographic location, published between 2000-2020, include water, sediment, and/or soil samples, were conducted in natural systems and/or laboratory studies with relevant data applied to natural systems, include data related to transformation by sunlight, biodegradation, and/or sorption processes, and include data for any of the following compounds: i) sulfonamides: sulfachlorpyridazine, sulfadiazine, sulfadimethoxine, sulfamethazine, sulfamethoxazole, sulfapyridine; ii) macrolides: erythromycin, roxithromycin, tylosin, azithromycin; iii) tetracyclines: chlortetracycline, doxycycline, oxytetracycline, tetracycline; iv) fluoroquinlones: ciprofloxacin, enrofloxacin, norfloxacin, ofloxacin; v) beta-lactams: penicillins; vi) others: carbadox, trimethoprim, lincomycin.
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    Risk assessment of feed ingredients of porcine origin as vehicles for transmission of Porcine Epidemic Diarrhea Virus (PEDV)
    (2015) Sampedro, Fernando; Snider, Tim; Bueno, Irene; Bergeron, Justin; Urriola, Pedro E; Davies, Peter R
    The objective of this project was to assess the likelihood that feed ingredients of porcine origin may function as vehicles of Porcine Epidemic Diarrhea virus (PEDV) transmission via feed. The scope of the assessment included rendered ingredients, ingredients derived through spray drying porcine blood, and ingredients derived by hydrolyzing porcine tissues. For any feed ingredient, the risk of the release of infective PEDV is a function of: (1) the concentration of PEDV in the raw materials; (2) the virus survival after ingredient processing (3) the survival of virus during post-processing storage and distribution; and 4) the likelihood of post-processing contamination incorporating PEDV into the finished ingredient. No data on PEDV contamination of raw materials were available for the rendering and hydrolyzed protein sources. Estimates of PEDV contamination of liquid plasma were available from industry, based on PCR testing of ingredients over time, and were used in quantitative modeling. The assessments made in this project were constrained by a paucity of specific data on several aspects that are germane to the risk of PEDV transmission in feed ingredients of porcine origin. Available data on thermal inactivation of PEDV indicate that risk of virus surviving the processes of rendering and hydrolysis (peptone production) are negligible. The time and temperature profiles used in spray-drying are much less severe, and therefore, the possibility of virus survival is inherently greater if non-thermal mechanisms are ignored. Overall, currently available data indicate that probability of PEDV surviving the spray-drying process and current commercial storage periods is extremely small. In the course of the project, several data gaps were identified that contributed to the uncertainty. Risk assessment is an iterative process and the findings of this report may be revised in the future if new knowledge becomes available.
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    Surveillance for highly pathogenic avian influenza A (H5N1) in a raptor rehabilitation center — 2022
    (2024-03-11) Hall, Victoria L; Cardona, Carol; Mendoza, Kristelle; Torchetti, Mia; Lantz, Kristina; Bueno, Irene; Franzen-Klein, Dana; hall2112@umn.edu; Hall, Victoria L; University of Minnesota The Raptor Center
    An ongoing, severe outbreak of highly pathogenic avian influenza virus (HPAI) A H5N1 clade 2.3.4.4b has been circulating in wild and domestic bird populations throughout the world, reaching North America in 2021. This HPAI outbreak has exhibited unique characteristics when compared to previous outbreaks. The global distribution of disease, prolonged duration, extensive number of species and individual wild birds affected, and the large impact on the global poultry industry have all exceeded historical impacts of previous outbreaks in North America. In this study, we describe the results of HPAI surveillance conducted at The Raptor Center, a wildlife rehabilitation hospital at University of Minnesota (Saint Paul, MN, U.S.A.), from March 28th – December 31, 2022. All wild raptors admitted to the facility were tested for avian influenza viruses using polymerase chain reaction (PCR) testing. All non-negative samples were submitted to the United States Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS) National Veterinary Services Laboratories for confirmatory HPAI testing and genetic sequencing. During the study period, 996 individual birds representing 20 different species were tested for avian influenza, and 213 birds were confirmed HPAI positive. Highly pathogenic avian influenza surveillance conducted at The Raptor Center contributed 75% of the HPAI positive raptor detections within the state of Minnesota, located within the Mississippi flyway, significantly augmenting state wildlife surveillance efforts. The viral genotypes observed in birds sampled at The Raptor Center were representative of what was seen in wild bird surveillance within the Mississippi flyway during the same time frame. Wildlife rehabilitation centers provide an opportune situation to augment disease surveillance at the human, wildlife and domestic animal interface during ongoing infectious disease outbreaks.
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    Systematic review protocol of the efficacy of prebiotics and probiotics in reducing the colonization and shedding of Campylobacter and Salmonella in broilers and turkeys
    (2020) Valeris-Chacin, Robert; Nault, Andre J.; Hwang, Haejin; Weber, Bonnie; Bueno, Irene; Johnson, Timothy J.; Pieters, Maria; Singer, Randall S.
    Use of prebiotics and probiotics as an alternative to antibiotics is increasing in poultry 16 production. However, there is still uncertainty about their efficacy in controlling the spread of 17 human pathogens in poultry. This paper describes the protocol for a systematic review assessing18 the efficacy of prebiotics and probiotics in reducing the colonization and shedding of 19 Campylobacter and Salmonella in broiler chickens and turkeys. The objective of this protocol is 20 to document the methodology that will be used for the systematic review a priori.