Between Dec 19, 2024 and Jan 2, 2025, datasets can be submitted to DRUM but will not be processed until after the break. Staff will not be available to answer email during this period, and will not be able to provide DOIs until after Jan 2. If you are in need of a DOI during this period, consider Dryad or OpenICPSR. Submission responses to the UDC may also be delayed during this time.

Browsing by Author "Bendale, Madhuri"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Impaired habit acquisition and striatal dysfunction in early Parkinson’s disease
    (2021-07) Bendale, Madhuri
    Parkinson's disease (PD) is characterized by the progressive degeneration of substantia nigra pars compacta (SNc) dopamine (DA) neurons resulting in striatal DA depletion and motor symptoms such as resting tremors, bradykinesia, rigidity, and postural instability. However, motor symptoms do not emerge until a large portion of SNc DA neurons are lost resulting in a premotor or prodromal phase of the disease. During the premotor phase patients may experience non-motor such as cognitive impairments, which adds to the overall disability of the disease. Utilizing a mouse model with progressive SNc degeneration, we investigated if habit acquisition which is governed by the dorsolateral striatum (DLS) was impaired during early PD. Our study indicates a trend for impaired habit acquisition, that was associated with increased intrinsic excitability of DLS indirect spiny projection neurons (iSPN). As SNc degeneration progressed, this iSPN hyperexcitability persisted and qualitatively appeared to be increased in magnitude.