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Browsing by Author "Abul-Hajj, Yusuf J."

Now showing 1 - 3 of 3
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    Aquatic Plants from Minnesota Part 3 - Antimicrobial Effects
    (Water Resources Research Center, University of Minnesota, 1972-02) Abul-Hajj, Yusuf J.; Staba, E. John; Su, K. Lee
    In this study the antimicrobial activity of the following 22 Minnesotan aquatic plants was investigated: Anacharis Canadensis, Calla Polustris, Carex lacstris, Ceratophyllum demersum, Chara vulgaris, Elecharis smallii, Lemna minor, Myriophyllum exalbescens, Nuphar variegatum, Nymphaea turberosa, Potamogeton amplifolius, P. natans, P. pectinatus, P. richardsonu, P. zosteriformis, Sagittaria cuneata, S. latifolia, Sparganium eurycarpum, S. fluctuans, Typha angustifolia, Vallisneria amiercana, and Zizania aquetica, Furthermore, the chemical constituents responsible for the significant antimicrobial effect were isolated and identified. The skellysolve F. chloroform, 80% ethanol and fresh water extracts of plant species were treated for antimicrobial activity employing the qualitative filter paper disc diffusion method and reference antibiotic discs. Ethanol (80%) extracts of Myriophyllum exalbescens (activity ratio of .34 as compared to the 30 mcg chloramphenicol discs) Nymphaea tuberose (leaf: .40, stem: .45) were moderately active against S. aureus. Ethanol (80%) extracts of Carex lacustris (activity ratio of .34 as compared to the 10 mcg streptomycin discs), Nymphaea tuberose (leaf: 1.01, stem: 1.10) and Nuphar variegatum collected in Lake Minnetonka (leaf: .73, stem: .58) were active against M. smegmatis. All extracts were relatively inactive against E. coli except the water extract of Potamogeton natans where a low activity ration of .10 as compare to the 30 mcg chloramphenicol discs was indicated. Skellysolve F stem extracts of Nuphar variegatum collected in the Pine Lake and Sparganium fluctuans showed a rather distinct action against C. albicans, the activity ratio as compared to the 100 units mycostatin discs were 2.06 and 1.08, respectively. Regarding antifungal activity, ethanol (80%) extracts of Carex lacustris (activity ratio of 1.08 as compared to 5% aq. Phenol standard), Nymphaea tuberosa (stem: .72) and skellysolve F extract of Potamogeton zosteriformis (.60) were active against Alternaria sp., 80% ethanol stem extracts of Nymphaea tuberosa and Nuphar variegatum were active against F. roseum with the activity ratios of .41 and .48 respectively, as compared to the 5% aqueous phenol standard. In general, the plant pathogenic fungi are more resistant than animal pathogenic organisms toward the actions of aquatic plant extract.
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    From Digitalis to Ziagen: The University of Minnesota's Department of Medicinal Chemistry
    (University of Minnesota Libraries Publishing, 2012) Abul-Hajj, Yusuf J.; Broderick, Richard
    A comprehensive history of Medicinal Chemistry beginning with the founding of the University of Minnesota’s College of Pharmacy in 1892 until today. In turn that same period of time—1892 to 2012—also represents the most revolutionary era in the history of the entire discipline of medicinal chemistry, witnessing the transformation of the field from an artisanal, trial-and-error approach to isolating and testing therapeutic elements in natural elements to today’s high-tech, computer-assisted discovery and design of new, targeted drugs.
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    Interview with Yusuf Abul-Hajj
    (University of Minnesota, 2012-08-06) Tobbell, Dominique A.; Abul-Hajj, Yusuf J.
    Dr. Yusuf Abul-Hajj begins his interview by reflecting on his education, his choice to pursue medicinal chemistry at the University of Wisconsin, the difficulties of transition and travel between Palestine and the United States, and the Arab community in Minneapolis. Dr. Abul-Hajj then describes his early career in the College of Pharmacy at the University of Minnesota, with particular attention to the clinical pharmacy movement, the creation of the Pharm.D. program, and problems that consequently arose within the basic science, research-oriented departments of the College. He then discusses the following topics: collaboration between the Department of Medicinal Chemistry and the Chemistry Department; the revival of social and administrative pharmacy; relations between clinical and basic science faculty in the College; collaborations between faculty in Medicinal Chemistry and faculty in the Medical School; the appointment of Gilbert Banker and his tenure as dean of the College; collaboration between Medicinal Chemistry and the pharmaceutical industry; his own research on estrogen and cancer; drug development in academia; and the creation of the Center for Drug Design.