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Please use this identifier to cite or link to this item: http://hdl.handle.net/11299/116891

Title: Chemical Stability of Hydrocortisone in Topical Preparation in Proprietary VersaProTM Cream Base
Authors: Sarkar, Arindam Basu
Dudley, Richard
Melethil, Srikumaran
Speidel, Jonathon
Bhatt, Gopalkumar Markandakumar
Issue Date: 2011
Publisher: University of Minnesota, College of Pharmacy
Citation: Sarkar AB, Dudley R, Melethil S, Speidel J, Bhatt GM. Chemical Stability of Hydrocortisone in Topical Preparation in Proprietary VersaProTM Cream Base. 2011; 3(54):1-3.
Abstract: The United States Pharmacopeia-National Formulary (USP-NF) suggests beyond use dating ((BUD) for compounded topical preparations containing active pharmaceutical ingredients (API) [1]. The beyond the use dates of the preparations are based on the conservative and empirical guidelines of USP 795. Hydrocortisone (HC) content compounded in the VersaPro™ base cream was quantified using a HPLC method at time zero and after 30 and 60 days of storage at both room temperature and 4℃. The analysis suggests that the compounded preparations retain > 95% of the stated initial potency of HC regardless of storage conditions. Thus HC creams prepared in VersaPro™ cream base can be safely assigned a beyond the use date of two months when stored at room temperature.
URI: http://purl.umn.edu/116891
ISSN: 2155-0417
Appears in Collections:Volume 02, Number 3, 2011

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