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Volume 02, Number 3, 2011 >
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| Title: | Chemical Stability of Hydrocortisone in Topical Preparation in Proprietary VersaProTM Cream Base |
| Authors: | Sarkar, Arindam Basu
Dudley, Richard
Melethil, Srikumaran
Speidel, Jonathon
Bhatt, Gopalkumar Markandakumar |
| Issue Date: | 2011 |
| Publisher: | University of Minnesota, College of Pharmacy |
| Citation: | Sarkar AB, Dudley R, Melethil S, Speidel J, Bhatt GM. Chemical Stability of Hydrocortisone in Topical Preparation in Proprietary VersaProTM Cream Base. 2011; 3(54):1-3. |
| Abstract: | The United States Pharmacopeia-National Formulary (USP-NF) suggests beyond use dating ((BUD) for compounded topical
preparations containing active pharmaceutical ingredients (API) [1]. The beyond the use dates of the preparations are based on the
conservative and empirical guidelines of USP 795. Hydrocortisone (HC) content compounded in the VersaPro™ base cream was
quantified using a HPLC method at time zero and after 30 and 60 days of storage at both room temperature and 4℃. The analysis
suggests that the compounded preparations retain > 95% of the stated initial potency of HC regardless of storage conditions. Thus
HC creams prepared in VersaPro™ cream base can be safely assigned a beyond the use date of two months when stored at room
temperature. |
| Permanent URL: | http://purl.umn.edu/116891 |
| ISSN: | 2155-0417 |
| Appears in Collections: | Volume 02, Number 3, 2011
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Files in This Item:
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Description |
Size | Format |
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| 11-066 Chemical Stability of Hydrocortisone article 54.pdf | | 482Kb | PDF | View/Open |
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