Intensive glycemic control (A1c ~ 7%) in patients with Type 2 diabetes mellitus has no significant effect on the rates of major cardiovascular events, death, peripheral neuropathy, and retinopathy compared with standard therapy (A1c ~ 8.5%) when measured within a mean 5.6 year treatment period. Intensive glycemic control does decrease the progression of albuminuria (P= 0.01) in this treatment window, but is associated with higher overall rates of adverse events (P = 0.05), including hypoglycemia (P < 0.001) and dyspnea (P = 0.006).
Intensive glycemic control in Type 2 diabetes mellitus has both benefits and risks: a review of the VADT study.
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