In patients with impaired fasting glucose and impaired glucose
tolerance, lifestyle intervention can delay or prevent the development of
diabetes by 58% over 3 years in all populations. Metformin can also delay or
prevent the development of diabetes by 31% over 3 years. However, the
effectiveness of metformin is limited to patients less than 60 years in age, with
a BMI > 30 kg/m2.