Post-Lyme syndrome happens in patients who received standard treatment of 2-4
weeks of antibiotics, but still have chronic symptoms. These symptoms include muscle
or joint pain, fatigue, memory or thinking difficulty, irritability, difficulty sleeping,
depression, headache, or limb weakness. These symptoms occur without lab evidence for
them such as markers of inflammation. Some clinicians suggest treatment with months of
antibiotics. However, in three large clinical trials, long term treatment with antibiotics
was the same as placebo in the treatment of these symptoms.
While there currently is no treatment to cure post-Lyme syndrome, it is important
for the patient to work closely with their physician to manage the symptoms.