HBB is a chemical compound being tested as a possible drug to treat breast cancer in addition to other hormone therapies. However, its mechanism remains unclear. This set of experiments was done to understand how HBB treated cells react upon exposure to either estradiol or progesterone. By using western blot assays, it was determined that phosphorylated ERK levels increased in cells treated with HBB.
This research was supported by the Undergraduate Research Opportunities Program (UROP).
Ji, Michelle, M.
Effect of N1-hexyl-N5-benzyl-biguanide mesylate (HBB) on Immediate Early Hormonal Signaling in MCF-7 Breast Cancer Cells.
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