Flow-mediated dilation (FMD) is a measure of endothelial function. This study aimed to explore the temporal relationship of time to peak FMD (FMDTTP) as well as time to peak shear stress (ShearTTP) between children and adults. Shear stress and FMD was assessed in 122 children and 350 adults using ultrasound. A p-value of 0.05 denoted significance. Peak FMD (p=0.022) and Peak Shear rate (p=0.0002), and were significantly larger in children than adults. FMDTTP was significantly slower (p=0.027) in children vs. adults. ShearTTP was slower in children than in adults (p=0.004). There was no significant difference (p=0.27) in time from ShearTTP to FMDTTP between children and adults. In the present showed children not only displayed a larger peak FMD, but also the time it takes the shear stimulus to reach its peak is significantly slower in children than adults. However, the time from peak Shear to peak FMD was similar.
University of Minnesota M.S. thesis. May 2014. Major: Kinesiology. Advisor: Donald R. Dengel, Ph.D. 1 computer file (PDF); v, 43 pages.
Evanoff, Nicholas George.
Peak shear and peak flow mediated dilation: a time course relationship.
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