Our society has become increasingly sedentary, which has resulted in numerous health complications. For example, there has been an increase in blood sugar regulation abnormalities, which can lead to pre-diabetes and eventually type 2 diabetes. This dissertation focuses on working women whom, upon initial screening, demonstrated a fasting blood sugar greater than 100 mg/dl. The participants completed two separate trials; 1) sitting and standing while completing an oral glucose tolerance test at work; and 2) sitting for one week followed by standing for one week at work while wearing a continuous glucose monitor and an accelerometer. The first Manuscript (Chapter 4) summarizes a randomized, cross-over pilot study evaluating the acute effect of standing at work on postprandial glucose. Results indicated a trend towards an improved postprandial glucose response during standing (Glucose iAUC = -124.9 ± 481.7, 95% CI [-386.7, 137]) relative to sitting. Manuscript II (Chapter 5) summarized a repeated measures pilot study examining the effect of standing in the workplace on blood glucose regulation over a one week period among women with impaired fasting glucose. Sedentary time significantly predicted blood glucose independent of physical acitivity (p = .015). Manuscript III (Chapter 6), also a repeated measures study, is a brief report examining the effect of a sit-stand desk on sedentary time during the work day among pre-diabetic adults. A nonsignificant reduction in sedentary time was found in the life, health, and combined life and health zones in the sit-stand condition relative to the sitting condition (life: 1.37 ± 2.77; 95% CI [-0.35, 3.08]; health: 0.55 ± 1.56; [-0.42, 1.52]; life and health: 1.92 ± 3.44; [-0.21, 4.05]; zone intensities are life < 2 mph, health 2-4.5 mph, and sport > 4.5 mph). Additional research should recruit larger sample sizes and examine the long-term effect of reducing sedentary time on blood glucose among working adults with impaired fasting glucose.
University of Minnesota Ph.D. dissertation. June 2014. Major: Kinesiology. Advisor: Beth Ann Lewis. 1 computer file (PDF); vi, 101 pages.
Acute effects of a sit-stand workstation on blood glucose regulation in working women with impaired fasting glucose.
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