Background: No model of nurse job satisfaction was found in the literature that had been empirically tested in Jamaica or surrounding countries in the Caribbean.Objective: The objective of this study was to test an instrument of nurse job satisfaction in Jamaica and use results to improve nurse job satisfaction at the unit level and refine efficiency of care delivery across the hospital.Methods: Convenience sampling was used to gather data in a 579-bed urban hospital in Southeast Jamaica regarding nurse job satisfaction, nurses' clarity of self, role and system, and demographics. Parceling of data was used in a confirmatory factor analysis (CFA) to test an 11-factor construct of nurse job satisfaction. Hierarchical regression was used to examine explained variance of nurse job satisfaction.Results: Complete surveys from 82 nurses (14% response rate) revealed good model fit for all 11 dimensions, including four social factors (satisfaction with relationship with coworkers, relationship with the patient, relationship with unit/ward manager, and relationship with physicians) and seven technical dimensions (satisfaction with resources, autonomy, staffing/scheduling, professional growth, executive leadership, distributive justice, and workload). Results revealed adequate fit, RMSEA .08, CFI .90, and SRMR .07. Path coefficients ranged from .35 to .72 (p = < .001 for all coefficients). The best fitting model for predicting nurse job satisfaction included service line (R = .475, R2 = .226, F (7,74) = 3.078, p = .007), and clarity of role (R = .543, R2 = .295, F (1,73) = 7.192, p = .009). Combined, both predictors explained 29.5% of the variance of nurse job satisfaction. Discussion: Data was presented to staff and management to understand the 11 dimensions of nurse job satisfaction in this sample in Jamaica. Results were presented at the aggregate hospital and unit level. Staff and management are currently using the results to make changes at the unit level, using the data to guide planning. This study met the objective to empirically develop, test, and use a model of nurse job satisfaction in Jamaica.