This dissertation presents a discussion of both perigestational dietary influence on
cancer predisposition as well as somatic genetic determinants of cancer development.
Both projects used genetically engineered mouse models of cancer. The introductory
chapter gives a brief historical introduction to cancer, background information on models
of cancer, and a short description of our current understanding of cancer. Chapter two
presents data on how maternal diet can affect the risk for medulloblastoma in offspring.
Medulloblastoma presents a dismal prognosis even for the patients who are successfully
treated. Prevention strategies are therefore of great interest in addressing this disease.
Chapter three discusses a mouse model of Histiocytic Sarcoma (HS) that was developed
to identify genes that can contribute to initiation and cause progression of disease. The
genetics of HS are not well understood. Our model could provide important information on molecular targets that can be used to treat this dreadful disease. The final, fourth
chapter, provides a brief and broad overview of some of the major future likely sources of
cancer control success with a focus on new research.
University of Minnesota Ph.D. dissertation. December 2012. Major: Comparative and Molecular Biosciences. Advisor: Dr. David A. Largaespada. 1 computer file (PDF); iv, 75 pages.
Been, Raha Allaei.
Insights into determinants of cancer susceptibility, initiation, and progression:studies on medulloblastoma and Histiocytic Sarcoma in mouse models.
Retrieved from the University of Minnesota Digital Conservancy,
Content distributed via the University of Minnesota's Digital Conservancy may be subject to additional license and use restrictions applied by the depositor.