Nerve conduction block elicited by high frequency electrical stimulation may be used to
create chronic neuroprostheses to treat diseases that are characterized by pathological
nervous activities. Previous studies have demonstrated that local and reversible nerve
conduction block can be achieved using high frequency stimulation (3-6 kHz and above)
delivered through cuff electrodes. However, cuff electrodes are designed to be placed
encircling the nerve and demands invasive surgical procedure that may not be desired by
patients in clinical applications. This study investigated the nerve block effect of high
frequency stimulation delivered through a percutaneous lead placed next a motor nerve
trunk in dogs. The optimal frequency and amplitude windows for nerve block using a
biphasic rectangular waveform were 10-30 kHz and 15-20 V peak-to-peak within the
tested parameter range (5-40 kHz and 5-20 V). Higher frequencies may require higher
amplitudes to achieve nerve block effect. In addition, activation threshold of the nerve
evoked by the biphasic high frequency stimulation also increased with frequency. The
HFS nerve block was repeatable in more than 40 minutes of repetitive stimulation. This study demonstrated that it is feasible to achieve local reversible nerve block using
percutaneous lead electrodes placed next to a nerve with biphasic high frequency
waveform. Although it may be difficult to block all the nerve fibers in a nerve trunk with
a percutaneous lead, partial nerve block can be clinically useful and desired in many disease conditions.
University of Minnesota M.S. thesis. Major: Integrarive biology and physiology. Advisor:John W. Osborn. 1 computer file (PDF); x, 46 pages.
Peripheral nerve conduction block with high frequency stimulation via percutaneous lead electrode..
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