TUF1 is a novel neuropeptide highly concentrated in the amygdala, hippocampus, hypothalamus, and the endocrine tissue. Due to the high concentration in these regions, it is believed that TUF1 may play a role in stress regulation and fear-learning.
Fear-learning is a form of Classical Conditioning. Fear is measured by Fear-Potentiated Startle (FPS). FPS is a valid and reliable method of measuring fear in rats. This study was conducted in the attempt to create a working FPS paradigm for mice in the Gewirtz Lab. After establishing this paradigm, we should be able to study the effects of TUF1 more efficiently
using TUf1 knock-out mice.