Objective and Hypothesis:
Investigate the therapeutic potential of NRAS-targeted therapy in the human MLL-AF9 and NRASG12V-driven AML cell line THP-1 using shRNA and small molecule inhibitors. We hypothesize that inhibition of NRAS using shRNA and inhibition of PI3K/AKT/mTOR and RAF/MEK/ERK pathways using small molecule inhibitors will lead to leukemic cell death.
This project was supported by a University of Minnesota Undergraduate Research Opportunities Program grant.
Hazen, Katherine; Eckfeldt, Craig; Largaespada, David.
Inhibition of NRAS signaling in an in vitro model of human MLL-AF9/NRAS^G12V acute myeloid leukemia.
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