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Chemical Stability of Hydrocortisone in Topical Preparation in Proprietary VersaProTM Cream Base
Sarkar, Arindam Basu; Dudley, Richard; Melethil, Srikumaran; Speidel, Jonathon; Bhatt, Gopalkumar Markandakumar (University of Minnesota, College of Pharmacy, 2011)
 

Title 
Chemical Stability of Hydrocortisone in Topical Preparation in Proprietary VersaProTM Cream Base

Issue Date
2011

Publisher
University of Minnesota, College of Pharmacy

Type
Article

Abstract
The United States Pharmacopeia-National Formulary (USP-NF) suggests beyond use dating ((BUD) for compounded topical preparations containing active pharmaceutical ingredients (API) [1]. The beyond the use dates of the preparations are based on the conservative and empirical guidelines of USP 795. Hydrocortisone (HC) content compounded in the VersaPro™ base cream was quantified using a HPLC method at time zero and after 30 and 60 days of storage at both room temperature and 4℃. The analysis suggests that the compounded preparations retain > 95% of the stated initial potency of HC regardless of storage conditions. Thus HC creams prepared in VersaPro™ cream base can be safely assigned a beyond the use date of two months when stored at room temperature.

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Other Identifier(s)
issn: 2155-0417

Suggested Citation
Sarkar, Arindam Basu; Dudley, Richard; Melethil, Srikumaran; Speidel, Jonathon; Bhatt, Gopalkumar Markandakumar. (2011). Chemical Stability of Hydrocortisone in Topical Preparation in Proprietary VersaProTM Cream Base. University of Minnesota, College of Pharmacy. Retrieved from the University of Minnesota Digital Conservancy, http://purl.umn.edu/116891.


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