The purpose of my project was to help design recombinant plasmids that would be used to create BACE1 proteins, which are involved in the pathogenesis of Alzheimer’s Disease (AD). BACE1 cleaves the amyloid precursor protein (APP) which is found in the cell membrane. Then γ-secretase cuts the resulting peptide, forming amyloid-β (Aβ) peptides. These Aβ peptides aggregate in the brain and cause plaques that lead to AD.
This project was sponsored by the Undergraduate Research Opportunities Project.
Synthesizing BACE1 Proteins to Investigate the Pathogenesis of Alzheimer’s Disease.
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