Whole organ decellularization is a promising technique to create 3D
scaffolds necessary to generate bioartificial organs. However, due to the
vital role of tissue mechanics in the contraction of the heart , it is
necessary to assess the changes to the myocardium caused by
Previous studies have demonstrated that heart tissue is anisotropic .
Ventricle tissue fibers are aligned in the circumferential direction, and
that orientation is preserved after decellularization . The
circumferential orientation of fibers is responsible for a higher stiffness
in that direction than the longitudinal direction . It has also been
proved that decellularized tissues have a higher tangential modulus than
cadaveric tissues .