Chiral compounds are being increasingly used as pharmaceuticals and agrochemicals to
limit potential side effects of a drug, such as the thalidomide tragedy, and to limit the
chemical load on the environment. Therefore it is important to be able to model
properties of chiral compounds so such side effects can be avoided. A new method to
encode information about the chirality of molecules is described herein. The Relative
Chirality Index (RCI) was devised to encode chirality information. This index was
shown to be useful to encode information about different molecules. The index is able to
differentiate one stereoisomer from another in a logical manner. An application of this
index to experimental data is also described.
University of Minnesota M.S. thesis. February 2011. Major: Chemistry. Advisors: Subhash Basak, Paul Siders. 1 computer file (PDF); vi, 31 pages, appendix p. 26-31.
Neumann, Terrence Sherman.
Relative chirality index: a novel approach to the characterization of molecular chirality..
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